Resveratrol, a phytoalexin found in the skin of red grapes and in red wine, has long been known to have health benefits, including the ability to control inflammation, but it was not known exactly how it achieved this effect.
New research has revealed that resveratrol stops inflammation by delivering a double whammy that prevents the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D.
In this study, a group of mice that were pretreated with resveratrol before being given an inflammatory agent were protected from developing inflammation, while mice that were not pretreated experienced a strong inflammatory response simulating disease in humans.
This work raises the hope that resveratrol – or a derivative – can be used to treat potentially deadly, acute inflammatory diseases such as appendicitis, peritonitis and systemic sepsis, and may also be of benefit in the treatment of other inflammatory conditions.
NB: This post is not intended to provide medical advice, diagnosis or treatment.