Posts Tagged ‘Beneficial Bacteria’

Getting real about antibiotics

Tuesday, March 23rd, 2010

While taking an antibiotic can, in some circumstances, be a life-saving intervention, it will also inevitably lay waste vast numbers of indigenous intestinal microorganisms – a loss from which we may only slowly, and possibly never completely recover, as less desirable organisms can win control in the repopulation process.

Our gut microbiota represents a ’second genome’ that is essential to our health, and any bacterial imbalance can have long-term consequences, due to the fact that we rely on beneficial bacteria to perform a number of crucial tasks such as digesting food, manufacturing vitamins and protecting us from invading pathogens.

When the normal, healthy balance of bacteria is knocked off kilter in the aftermath of antibiotics, the stage may be set for the development of a range of diseases, including Crohn’s disease, ulcerative colitis, food intolerance, and even obesity.

In addition to this, any use of antibiotics has the potential to encourage drug resistance on the part of bacteria, leading to the possible development of new ’superbugs’.

Until recently, the process by which antibiotic resistance develops had been thought to be a passive phenomenon, occurring when a mutation or a bit of newly acquired DNA enables a microbe to evade the effects of antibiotics or render them harmless. Natural selection was thought to then allow these particular microbes to outcompete their non-resistant peers.

However, in the last 6 years, researchers have discovered that mutation rates in bacteria may respond to other factors, such as the production of free radicals in response to antibiotics, which can then cause mutations in bacterial DNA, including some that happen to cause resistance.

A new study explains how this can occur as a result of using lower strength, non-lethal antibiotic concentrations, and how the resulting resistance may not be limited to the particular antibiotic used, but affect other antibiotics as well.

Put simply, antibiotics are not only selecting specific mutations, they are actually causing them.

And the issue of increased antibiotic resistance is not just a problem in clinical settings, but also in the wider environment. New evidence shows that even soil microbes have become progressively more resistant to antibiotics over the last 60 years, and that this has even occurred in the Netherlands in spite of stringent rules on the use of antibiotics in medicine and agriculture and improvements to sewage treatment technology.

It’s clearly a no-brainer that antibiotics should be reserved for life-threatening situations, rather than being squandered on every run-of-the-mill infection that develops. And it also seems madness to continue to allow the value of these drugs in combatting serious infection to be compromised by routinely injecting chickens and dosing pigs and cattle to promote animal growth and producer profits, when the result is low-level exposure to all who eat these animals. While Europe now eschews the use of antibiotics for growth promotion, US farmers apparently remain unpersuaded about the need for this change.

There is really no need to use antibiotics for everyday infections in humans because there are effective natural alternatives to pharmaceutical antibiotics which are ideal for this purpose.

Arguably the best natural antibiotic is colloidal silver, which is actually far safer, more effective and less expensive than the side effect-laden mainstream antibiotics, contrary to the disinformation about this substance that continues to be regurgitatied by mainstream medicine. Even the best and strongest of FDA-approved antibiotics are only effective for a handful of bacteria at best, whereas colloidal silver is effective on a much broader scale and can kill even the most deadly pathogens. Used sensibly, colloidal silver is entirely harmless to humans and it does not create resistance or immunity in the pathogens it kills.

Additional effective, safe and cheap natural antibiotics have recently been discovered in the form of essential oils, which are even able to combat drug-resistant hospital superbugs. Thyme and cinnamon were found to be particularly efficient against a range of Staphylococcus species, with thyme being able to almost completely eliminate bacteria within 60 minutes.

Clearly, the best course is to avoid infection in the first place, and a healthy diet and healthy lifestyle will go a long way towards this goal by enhancing immunity. In particular, the optimisation of one’s vitamin D level will effectively seal the fate of most marauding pathogens, as demonstrated by this must-read article. And vitamin D is very ably supported by vitamin C, a very potent nutrient that continues to be cold-shouldered by mainstream medicine as a result of the double standards applied by Western medicine when assessing the efficacy of vitamins compared with pharmaceutical drugs.

Probiotics can also assist in preventing infection, as shown by yet another new study that has added further data in support of this approach, which is both safe and non-invasive, and does not create bacterial resistance. Moreover, it was found that not only are harmless probiotics able to protect animals against falling prey to pathogenic bacteria, but they can also treat an existing infection, and can do so as effectively as the best available antibiotics.

Finally, if you want a vital and vigilant immune system, be careful what pharmaceutical drugs you take, as some can prevent the body’s attempts to fight invading organisms. For example, the statin drug, simvastatin, which is widely prescribed to prevent cardiovascular disease, actually impairs the ability of macrophages to kill pathogens, and then, in a double whammy, it goes on to enhance the production of cytokines that trigger and sustain inflammation.

Related articles:

Fluoroquinolone antibiotics – avoid like the plague

Kefir benefits the sickest young children on antibiotics

Good bugs prevent colds and flu

‘Friendly’ bacteria: side-lined healers

Appendix: backup bug bank

Thursday, January 7th, 2010

When my appendix was removed, many years ago, I was assured by my doctor that it was just a useless vestige – all that remains, according to Darwin, of a much larger organ, the caecum.

However, recent observations and experiments have disproved Darwin’s theory, and suggest that the appendix may have a use after all – as a ’safe house’ where beneficial commensal bacteria can ride out bouts of diarrhoea, before emerging to repopulate the gut.

The internal walls of the intestine are coated by biofilm, a thin, delicate layer consisting of microbes, mucous and immune system molecules, the role of which is thought to be the protection of good bacteria. These biofilms extend into the appendix, where they are even more pronounced.

The location and position of the appendix are such that, even if diarrhoea is severe enough to flush away the entire contents of the bowels, including its biofilms, the beneficial bacteria within the appendix are likely to remain intact, and able to repopulate the lining of the intestine before more harmful bacteria can take over.

The appendix also has other benefits, such as the manufacture of white blood cells, antibodies and associated chemicals, and it’s presence reduces the risk of developing Crohn’s disease. Furthermore, it can, if necessary, be used in reconstructive surgery, to provide a substitute ureter, for example, or an effective sphincter for a reconstructed bladder. So this seemingly insignificant appendage is not something to be cast aside lightly.

The problem with the appendix is that it is prone to inflammation (appendicitis) which hospitalises 320,000 and kills up to 400 Americans each year. This inflammation has, since Darwin’s time, been thought to be due to a defect in the appendix, such as obstruction of its opening. However, it now appears that Darwin was probably also wrong about this, and it is much more likely that the appendix has fallen foul of the effects of the cultural changes and improved sanitation that are associated with industrialisation and which have left the human immune system with far fewer legitimate targets, thus exposing our own tissues, including the appendix, to its marauding agents.

The author of the first-ever historical study of the appendix suggests that, now that we have a better understanding of the function of the appendix and the effects on it of modern lifestyles, we should be looking for ways to challenge our immune system in much the same manner that it was challenged back in the Stone Age. He of course anticipates that this will eventually be achieved by the use of synthetic medicines, and is seemingly unaware that the immune system can already be effectively challenged by reintroducing some of the organisms that were, for millennia, the natural quarry of the immune system - ‘old friends’, such as helminths.

By reinstating a few benign intestinal worms (available from Autoimmune Therapies), we can introduce an effective mechanism for controlling inflammation throughout the body and thereby not only reduce the liklihood of our appendix becoming inflamed and needing to be removed, but also ensure that we will continue to benefit from the valuable functions that we now know are performed by this odd little organ.

Probiotic lozenges promote oral health

Tuesday, September 8th, 2009

The world’s first probiotic lozenge, designed to promote oral health by restoring the natural balance of bacteria in the mouth was GUM PerioBalance, which contains the patented ingredient Lactobacillus reuteri Prodentis.

Another probiotic lozenge is now available which its makers claim will also provide protection against the harmful bacteria that cause dental plaque by repopulating the mouth with beneficial bacteria.

Named Advanced Oral Hygiene, the new lozenge contains the probiotics S. salivarius and B. coagulans, two strains of bacteria which have been shown to help maintain healthy teeth and gums. The lozenge’s makers recommend taking the product once or twice each day after brushing one’s teeth.

There may be additional benefits from ingesting these bacteria, including a reduction in bad breath and a lowering of inflammation generally throughout the body. Studies have shown that ingestion of S. salivarius helps to reduce halitosis and also to inhibit systemic inflammatory cytokines. B. coagulans has been shown to enhance white blood cells’ surveillance for bacterial invaders, boost immune response to a simulated bacterial attack, and enhance the activity of natural killer cells.

Good bugs prevent colds and flu

Thursday, July 30th, 2009

According to a study done in China, children who were regularly given probiotic bacteria during the winter had fewer colds, needed fewer antibiotics, and missed fewer days of school. Those who did succumb to infection recovered more quickly if they were taking the probiotic, and the benefits were even more marked in the case of a group who received two types of bacteria – Lactobacillus acidophilus and Bifidobacterium animalis.

Research had previously shown that probiotics can benefit those who are already ill with various conditions, possibly by boosting the immune system’s response to invaders, but it was previously not clear whether beneficial bacteria were effective in preventing sickness.