For the therapeutic use of benign infectious organisms in the treatment of immunological disease

July 9th, 2009 by admin

This is an article I originally posted to Gather, which I quickly grew to dislike as a site. Really weird members, lots of ads and weird incentives based on points to post stuff.

So I expanded the article and posted it to K5, where I had originally posted about my experiences going to Cameroon to infect myself with hookworm. That post was never completed, I did not understand when I wrote the incomplete first draft how it worked. When I woke up the next day it had already been locked and was being voted on for publication. Therefore it contains some basic errors, ones I had intended to correct when coming back to edit it. You can read that original post here about my trip to Cameroon: link.

But I am quite proud of the article I wrote referenced in the title of this blog post, and available here.

It lays out the case in broad strokes for the use of benign infectious organisms to prevent and treat disease. A concept I am considering turning into a book, but of course wondering if I have the self-discipline, time and skills to produce.

From the post:
Because of my experience going to Cameroon, first written about here in 2006, to infect myself with hookworm to deal with my allergies and asthma, and because of my role as the founder of the world’s first company offering infection with human hookworm and whipworm to the public, I was approached by a documentary film maker a while ago. I agreed to be filmed but quickly became unhappy with the direction they were taking. They were more interested in our personal lives and an Oprah-like approach to the story than in the science or the implications for the practice of medicine. To try and persuade them to do a movie I was interested in watching, and that I was willing to continue to participate in filming, I wrote the following, believing that doing so would compel them to take a different approach. Who would not prefer to make the first documentary about something historic? I am still waiting for their response but it occurred to me that what I had written was a nice summation of my perspective on what I have learned since I started down this path and of my thinking about this approach to medicine.

Antibiotics take toll on beneficial microbes in gut

July 9th, 2009 by admin

This article ties in nicely with our observation that amongst some of our clients in or near full remission thanks to helminthic therapy antibiotics of some kinds can trigger a temporary return of their disease symptoms, like allergies, asthma and Crohn’s.

The recovery can take more than a month, which also ties in with the article.

In mice, recovery of microbiota that aid immune system is slow, incomplete

ANN ARBOR, Mich. — It’s common knowledge that a protective navy of bacteria normally floats in our intestinal tracts. Antibiotics at least temporarily disturb the normal balance. But it’s unclear which antibiotics are the most disruptive, and if the full array of “good bacteria” return promptly or remain altered for some time.

In studies in mice, University of Michigan scientists have shown for the first time that two different types of antibiotics can cause moderate to wide-ranging changes in the ranks of these helpful guardians in the gut. In the case of one of the antibiotics, the armada of “good bacteria” did not recover its former diversity even many weeks after a course of antibiotics was over.

Article continues here.

Stomach Bacterium May Thwart Asthma

July 9th, 2009 by admin

More evidence for the hygiene hypothesis and old friends hypothesis, as if more were needed.

WebMD published an article, obviously derived form some piece of science, that demonstrates bacteria in the gut can protect against asthma.

From WebMD:

Helicobacter Pylori, Which Can Cause Ulcers, May Make Asthma Less Likely

A stomach bacterium that causes ulcers and is linked to stomach cancer may make asthma less likely.

That news appears in the Archives of Internal Medicine.

The bacterium is called Helicobacter pylori (H. pylori). It is associated with ulcers and increased risk of stomach cancer.

H. pylori is found worldwide, but it’s more common in developing countries, note Yu Chen, PhD, MPH, and Martin Blaser, MD.

Chen and Blaser work at the New York University Cancer Institute; Blaser also works with the Department of Veterans Affairs New York Harbor Healthcare System.

Obviously no one wants stomach cancer as the price for not having asthma, but if one bacteria offers protection others certainly do as well.

Read more here.

Reason vs. belief

July 8th, 2009 by admin

The last four years have been one example after another of the unwillingness of most people to listen to reason, science and fact-based evidence when asked to reconsider things they “know”.

I am not unsympathetic to this, it was only in extremis that I found helminthic therapy and the patience to sift through the evidence for more than a year before trying it.

But when I post links to science on someone else’s blog or send them a message through MySpace or similar with links to science and evidence, only to get a reply like:

TIMBO replied to your forum post:
Hi.

You’re an idiot.
————————————————————–

This from a doctor, a scientist, who is supposed to be objective and open to evidence! It reminds me, again, of just how long persuading any significant number of people to try this is going to take based on science, reason and evidence.

Oprah, where are you?

I messaged him privately with:

I get it
Body:
I have been dealing with your type of response to my Crohn’s post for years.

But if you really are devoted to science and reason in medical decisions you owe yourself and your audience the time and trouble to read the science I offered you.

You can download a lot of it here, although you will need a decent compression utility to decompress the .tgz archive.
download Crohn’s-helminth literature here.

I am happy to debate this by email or telephone.

9/10 of those with Crohn’s we treat experience on average a 4.5/5 level response within six months.

On top of that the CDC recommends that American doctors, in their hookworm diagnosis and treatment algorithm NOT treat light infections with hookworm.

Light infections are all we sell.

Imagine for a minute that I am neither a charlatan or a lunatic. Please read the science.

You can call me at 831 818 2766.

END

The above link remains active if anyone reading this is interested in the science.

Jasper

Welcome

July 5th, 2009 by immunotherapy

A little about me and Autoimmune Therapies:
I first infected myself with the type of parasites known as helminths, specifically human hookworm, in January of 2006.

I had to go to Cameroon to do so, and after my asthma and allergies went into remission as a result, I realized that I could help others by making hookworm available without the requirement of dangerous and uncertain travel to the tropics.

Three years later we have infected around 90 people with excellent results, and the company I helped found, Autoimmune Therapies, continues to grow, attract new clients, and a lot of media attention.

This blog and the others here is an attempt to make more and richer sources of information about the Hygiene Hypothesis and related ideas available to more people.

Immunotherapy based on the use of benign infectious organisms like helminths will one day, I believe, come to dominate the field of immunology. Much of health care will become the management of the beneficial organisms we will be deliberately infected with, like probiotics. But including a larger variety of organisms beyond the bacteria and yeasts commonly used now. Specifically helminths and protozoa, organisms we, and in particular our immune systems, co-evolved with will be used to prevent or treat a host of immunological and chronic inflammatory conditions. I also believe the types of organisms used for a given individual will eventually be determined based on the genetics of the patient, so that this therapy will intersect with genetic research, the idea that treatments will be tailored to one’s genes.

Since obtaining hookworm I have since also infected myself with human whipworm, without any ill effect.

This should not be surprising as the CDC recommends that American doctors not treat light infections of either hookworm or whipworm.

I hope you enjoy your time here and find something useful in your quest for health if you are sick.

Unintended Consequences

July 5th, 2009 by immunotherapy

The hygiene hypothesis is really the story of unintended consequences associated with the well intentioned efforts to eliminate infectious diseases, like Cholera, Typhoid and Smallpox.

That the lessons of these, and similar well intentioned efforts and their unintended consequences, have not been integrated into the adoption of various technologies is shocking, except that our system is not designed to consider such issues.

And so we can expect this type of phenomena to continue, until its logical conclusion.

http://science.slashdot.org/article.pl?sid=09/07/03/2241207

Essentially memes are driving human evolution, not genes, which of course is obvious to anyone with an immunological disorder related to how we have molded our environment in ways deleterious to our genes.

This concept is at the core of not just the hygiene hypothesis, but the Paleolithic diet, that vitamin D deficiencies due to lack of exposure to sunlight may be a contributing factor to various human diseases, that the rise of obesity is due to the fact that we don’t exercise as much as we used to, that computer games are altering the way our children develop social skills, and a hundred other concepts related to the impact of “civilization” on human health, psychology and behavior.

The hygiene hypothesis confirmed by Stephen Hawking, not that is was required, but thanks, doctor.

What is enormously disturbing to me is that memes, ideas or beliefs transmitted like genes from individual to individual, drive natural selection not on the basis of individual fitness, but on group fitness. Witness the impact of agriculture. Agriculture succeeded as a meme despite the fact that it reduced life-expectancy, stature and quality of life for most individuals because it enabled cultures that adopted it to wipe out cultures that did not. A thousand short, weak and short-lived warriors are better than a hundred healthy, tall, and long-lived ones.

We now live in an age in which the determinant of fitness, and the transmission of biological information is no longer determined by just genes, but by memes. The organism carrying those pieces of information (genes or memes) are no longer just individuals, but societies. Whether I breed and my genes get passed on has as much to do with the collection of memes our society carry as the genes that I carry, as well as the subset of of our culture’s memes that I have integrated into my life. Do I drive a nice car, am I a fit mate? These things are determined as much by my ideas and attitudes as by my genetic heritage. Please don’t get cute and argue that the memes I carry are determined by my genes. True, but meaningless in this context.

It was not until the late 20th Century, and only in the USA and Western Europe, that humans regained the life expectancy and stature (5′ 11″ for men) that paleolithic hunter-gatherers had enjoyed before the advent of agriculture, ten thousand years previously. Please see Guns, Germs & Steel, and the Paleolithic diet.

You and I don’t matter in a country, or more correctly a social organism, in which each individual represents one “cell” in 300,000,000. If I die or get sick it is as if you were to trim your finger nails. I just don’t matter as I would in the type of social organism we evolved in, a village or tribe numbering perhaps a hundred.

Don’t even get me started about the price mechanism as the final determinant of what is wonderful and desirable.

How can anything that puts no value on a sunset, love, or clean air be the final word on the allocation of resources? But that is what we are expected to believe. Capitalism has given you HD Televisions, freeways, mayonnaise, and therefore is so wonderful that it is heresy to question it.

Why is it that no effort or resources are put into evaluating the impact of technology before it is thrown into the pool to be evaluated by the market?

Sure, I cannot buy my own personal nuclear weapon, but I can buy the equipment, material and instructions for assembling the Smallpox virus. It may cost a lot now, and take years for me to accomplish, but as we have seen with technology time and time again, in a few years or decades alienated teenagers will be able to code real viruses, not just computer viruses, using equipment available for at most a couple of thousand dollars.

Doubt me? Why ban something that isn’t possible? http://www.sciencemag.org/cgi/content/summary/307/5715/1540a. A few years ago a scientist did a proof-of-concept in which he assembled some random virus using off the shelf equipment, freely available instructions, and mail order proteins, components, and enzymes. He did it part time while he worked on his day job and it took a couple of years, but he did it. Pity I cannot find the news articles describing it, but it is out there.

It is no great leap from that to http://www.newsweek.com/id/204235. Newsweek cheerleads while no one asks whether or not this is desirable. Nor is there any mechanism available to us, except for spending our increasingly scarce money, in which we can vote on whether or not this is a desirable direction for research. You don’t have to be religious to be disturbed by the idea of humans creating life or combining it as casually as a DJ mixes music beats to create a new tune for humans to dance to.

And dance we will.

This issue goes to the core of what it means to be human and the choices we make as a nation and species, and so far we are blowing it in almost every respect.

This might just be bile built up from arguing with the world on the basis of reason, science, and evidence against the herd mentality and collective “wisdom”.

But I don’t think so.

Jasper