Posts Tagged ‘Dental Health’

We Need Our Symbiotes

Monday, December 14th, 2009

My next post will be on avoiding food poisoning, but before I post on that issue I need to point out that there obviously exists a balance between living in disease causing filth and being obsessively hygienic.  A lot of research suggests that we need various probiotics in order to be healthy, and that a large number of health problems occur because we have cleaned up our environment so thoroughly that we don’t have the necessary symbiotes in our bodies any more. 

The hygiene hypothesis seems to be gradually being refined into what has been called the Old Friends Hypothesis.  The shift is from one of believing that we benefit from infections with various organisms in general sort of way, to saying that bad organisms are bad for us, and good organisms (symbiotes) are good for us.  So, obviously we should try to avoid the bad ones and seek out the good ones.  Here are two previous blog posts of mine that touch on this issue The Umami Hypothesis – Lost Wanderer and Apitherapy & Biotherapy – Lost Wanderer

Here is a general survey of some of this material by Gut Buddies: ‘Friendly’ bacteria: side-lined healers - Gut Buddies (Some of the friendly bacteria (and products) referred to by Gut Buddies in this post are: segmented filamentous bacterium, Lactobacillus acidophilus and Bifidobacterium animalis, Bifidobacterium infantis 35624, Puritan’s Pride, Lactobacillus reuteriB. infantis 35624, Lactobacillus F19, L. acidophilus NCFB 1748 and B. lactis Bb12, Advanced Oral Hygiene with S. salivarius and B. coagulans, PerioBalance with Lactobacillus reuteri Prodentis, Halofuginone, and Bacillus polyfermenticus). 

Helminths (hookworms and whipworms, etc.) have been apparently very effective in helping with numerous allergic and autoimmune conditions, including allergies, asthma, autism, Crohn’s Disease, Eczema, Irritable Bowel Syndrome, Multiple Sclerosis, Psoriasis, Sjögren’s Syndrome, and Ulcerative Colitis. (AutoimmuneTherapies) (Hookworms are our Little Friends - Lost Wanderer)

Similar immune-modifying symbiote-based therapies might help with many other diseases and conditions: 

Alzheimer’s (Alzheimer’s Inflammation May Trigger Alzheimer’s Disease via Autoimmune & biotherapy news 2009/7/9 – Gut Buddies) (See also: Alzheimer’s – Lost Wanderer)

Aortic dissection (Inflammation Critical in Aortic Dissection, Researchers Find via The worm’s next success? – Gut Buddies)

Autism (Autism May Be Linked to Mom’s Autoimmune Disease (type 1 diabetes, rheumatoid arthritis and celiac disease) via Autoimmune & biotherapy news 2009/7/9 – Gut Buddies) (See also: The Vitamin D Theory of Autism – Lost Wanderer)

Dental Issues (Probiotic lozenges promote oral health - Gut Buddies (GUM PerioBalance (Lactobacillus reuteri Prodentis) and Advanced Oral Hygiene lozenges (S. salivarius and B. coagulans)

Depression (Is Dirt the New Prozac? by Josie Glausiusz (concerning the common soil bacterium, Mycobacterium vaccae)

Diabetes (Diabetes- Lost Wanderer)

Diarrhea (Kefir benefits the sickest young children on antibiotics - Gut Buddies)

Flatulence Odor (You Can be a God/Goddess – Lost Wanderer (Odafree/Whiff withYucca Shidgera from desert Yucca, Fructo-oligosacharides from Jerusalem artichokes, and Copper Chlorophyllin from alfalfa. Local inventor clearing the air on pill that helps you breathe)

Gastric reflux (Reflux Esophagitis Due to Immune Reaction, Not Acute Acid Burn via The worm’s next success? – Gut Buddies)

Migraine Headaches (Migraine Headaches - Lost Wanderer)

Narcolepsy (Narcolepsy Is An Autoimmune Disorder, Stanford Researcher Says via Autoimmune & biotherapy news 2009/7/9 – Gut Buddies)

Obesity (Study Confirms: Your Hidden Food Allergies Are Making You Fat via Give microbes to mum for less-allergic young - Gut Buddies)

(Probiotics may reduce belly fat in women (Lactobacillus and Bifidobacterium) via Obesity As An Immune Disorder – Matt Metzgar)

(Early differences in fecal microbiota composition in children may predict overweight (Staphylococcus aureus) via Obesity As An Immune Disorder II – Matt Metzgar)

(Childhood: Food Allergies May Be Linked to Obesity by Nicholas Bakalar and The Effect of The ALCAT Test Diet Therapy for Food Sensitivity in Patient’s With Obesity via Obesity As An Immune Disorder III – Matt Metzgar)

(Obesity – extending the hygiene hypothesis via Microflora - Matt Metzgar)

Obsessive-compulsive disorder (Link Discovered Between Antibodies To Strep Throat Bacteria And Obsessive Compulsive Disorder (and Tourette syndrome) In Mice (Group A beta-hemolytic streptoccoccus (GABHS)) via The worm’s next success? – Gut Buddies

Schizophrenia (Schizophrenia - Lost Wanderer) (Immune System Activated in Schizophrenia via The worm’s next success? – Gut Buddies)

Vaginosis (Bacterial vaginosis treatments: Probiotics can increase effectiveness of some antibiotic therapies via Autoimmune & biotherapy news 2009/7/9 - Gut Buddies)

Recently, Matt Metzgar has been posting a lot on the topics of probiotics (1) and prebiotics.  Matt began by pointing out the site Paleobiotics, which discusses how the ancient diet influenced people’s gut flora.  The diets of hunter gatherers would have had a lot of indigestible fibers in them, which were instead consumed by our gut bacteria.  Since we no long eat this sort of diet we harbor somewhat different colonies of bacteria, to the likely detriment of our health.  Matt points out that in one study (Can vegetables help you resist infection?) that men who took prebiotics massively increased their good gut bacteria, but the group only taking a probiotic didn’t benefit very much. (See also: Eat Bugs. Not Too Much. Mainly With Plants via Prebiotics versus Probiotics - Matt Metzgar) 

Conditions that Matt talks about that might be influenced by the types of bacteria we harbor include:

Allergies  (The role of Probiotics in allergic diseases, Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease, (bifidobacteria) Babies, Bacteria and Breast Milk: Genome Sequence Reveals Evolutionary Alliance (Bifidobacterium longum supsp. infantis) via Balancing Bacteria - Matt Metzgar and Babies and Bacteria – Matt Metzgar)

Anxiety, in patients with chronic fatigue (A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome (Lactobacillus and Bifidobacteria) via Probiotics and Mood – Matt Metzgar)

Chronic diarrhea (Don’t poo-poo technique: Fecal transplant can cure superbug, doctors say via Transplanting Good Bacteria - Matt Metzgar)

Cold and flu symptoms in children (Probiotic effects on cold and influenza-like symptom incidence and duration in children, (Lactobacillus acidophilus or L acidophilus NCFM in combination with Bifidobacterium animalis) and HOWARU  (Bifidobacteria and Lactobacilli) via Probiotics for Children – Matt Metzgar)

Dental Issues (EvoraPlus via Probiotics and Oral Health - Matt Metzgar)

(The effects of manuka honey on plaque and gingivitis: a pilot study, Streptococcus mutans in saliva of normal subjects and neck and head irradiated cancer subjects after consumption of honey via Honey and Oral Health - Matt Metzgar)

(Peelu, Comparative effect of chewing sticks and toothbrushing on plaque removal and gingival health, Subgingival plaque microbiota in Saudi Arabians after use of miswak chewing stick and toothbrush, Chewing sticks versus toothbrushes via Chewing on Fiber II - Matt Metzgar)

(Toothbrushing with vegetable oil: a clinical and laboratorial analysis via Brushing with Vegetables - Matt Metzgar)

(Dietary fiber intake and dental health status in urban-marginal, and rural communities in central Mexico  and A longitudinal study of the relationship between diet intake and dental caries and periodontal disease in elderly Japanese subjects via Chewing on Fiber - Matt Metzgar)

(See also: Dental Related Information – Lost Wanderer)

Hypertension (The Improvement of Hypertension by Probiotics: Effects on Cholesterol, Diabetes, Renin, and Phytoestrogens via Hypertension and Probiotics – Matt Metzgar)

(1) In addition to the conditions mentioned in this post, probiotics might also help with such things as lactose intolerance, colon cancer, cholesterol, improving immune function and preventing infections, improving mineral absorption, preventing harmful bacterial growth under stress, and managing urogenital health.  (Probiotic – Wikipedia)

Dental Related Information

Thursday, October 29th, 2009

My short list of advice for maintaining your dental health is:  Brush and floss after every snack and meal.  Water-pick also whenever you can.  Get your teeth checked and cleaned every 6 months.  Get that tool to identify plaque at home (see below).  Don’t suck on citrus fruits.  Don’t chew on ice.  Don’t hold metal nails in your mouth when hammering.  Try to avoid Epstein-Barr.  Don’t drink energy drinks, sports drinks, fitness water, and cola.  For now, drink fluoridated water.  Use xylitol and take vitamin K2.  If you want to use an electric toothbrush, get the oscillating kind.  Get your teeth sealed.   Get amalgam fillings for now, but keep an eye on new materials as they come along.   Drink lemonade or ice tea through a straw, and rinse immediately afterwards, then brush as soon as possible.

Defenders of amalgam fillings point out the following facts:  A person with 7 amalgam fillings (the average) absorbs about 1 microgram of mercury daily.  You get about 6 micrograms a day from food, water, and air. You would need to get around 45 micrograms a day to have the slightest risk of the being able to detect any blood changes signaling the beginnings of mercury’s effects.  A study of Portuguese children showed no evidence of neurological problems from dental fillings.  The findings showed no detectable loss of intelligence, memory, coordination, concentration, nerve conduction, or kidney function during the 5-7 years the children were followed. (Dental Tooth Fillings Containing Mercury Don’t Affect Children’s Brain Development, Study SuggestsStudies Evaluate Health Effects of Dental Amalgam Fillings in Children)  (But, for a contrary view see: Root Canals, Extractions and Mercury Amalgam Fillings)

As far as filling baby teeth, according to a recent literature review there isn’t enough evidence to be able to say which filling materials is best among the various types used. (No Clear Winner Among Fillings For Childhood Cavities, Types of Fillings, and Dental Filling Options – American Dental Association)

Also, dental mercury accounts for less than a quarter of a percent of all environmental mercury pollution.  Currently available composite fillings cause more secondary cavities, sometimes slowly release bisphenol A, may contribute to plaque formation, don’t last nearly as long, cost more, and are often not covered by insurance. (Amalgam Fillings Are Safe, But Skeptics Still Claim Controversy, Researcher Says)  

However, people are still concerned about amalgam, and in the quest to improve dental materials scientists have developed a replacement for it that is made from bile acids.  These are acids that are produced by your liver and stored in your gallbladder.  They claim it is hard, durable, and strongly resistant to cracking.  (Stronger Material For Filling Dental Cavities Has Ingredients From Human Body, and Scientists develop dental filling using bile acids)  And researchers have found that braided polyethylene fibers can be added to non-amalgam composite fillings that will increase their toughness by up to 433%. (Fibers Used In Bullet-proof Vests Quadruple Toughness Of Dental Composites)

Dentists have been using dental sealants with success for years, (Dental Sealants) although some people have questioned their safety. (Dental sealant safety reconsidered – new research fails to find environmental hormone risk)  Sealants work by preventing decay from starting in the nooks and crannies of your teeth.  

Following similar reasoning, researchers have adopted technology from the semiconductor industry that enable them to polish teeth to the nanoscale smooth level.  The idea is that they become too smooth for bacteria to cling to, and then they can be removed easily through brushing.  (New Tooth Cavity Protection: Nanoparticles Make Surface Too Slippery For Bacteria To Adhere)

It turns out that manual toothbrushes work just about as well as electric ones at reducing plaque and gum disease.  Researchers looked at 40 years of research, including 29 high-quality trials, and found that the only electric toothbrushes better than manual ones (by 11% with plaque and by 6% with gingivitis in three-month trial) were those where the head of the toothbrush rotates back and forth in an oscillating motion.  (Manual toothbrushes work just as well)  

I will mention several topics here I have blogged about before.  Xylitol is a naturally occurring sugar in many fruits and vegetables, prevents cavities, and has a very low glycemic index. (Food from Finland, and Xylitol - Lost Wanderer)  Vitamin K2 plays a vital role in the development of facial bones, as well as providing possible protection against cavities.  It normally enters the diet through eating the meat of grass fed – not grain fed - animals.  (Vitamin K2 – Lost Wanderer, On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved By Chris Masterjohn)  Periogen is a product that is purported to dissolve tartar. (Dissolve Tartar with Periogen – Lost Wanderer)

I haven’t investigated the issue of fluoridation enough to have an informed opinion.  All I can say is that one side of this debate is either delusional or lying.  Here are some sites that discuss it:  (Fluoride Action NetworkWater fluoridation - Wikipedia, Safety – Fluoride Information Network, Community Water Fluoridation – CDC, Is Fluoride Safe? By Charles Wilson, DDS, and 150+ Fluoride Facts, horror stories and cover-ups by Floyd Maxwell, BASc) 

Scientists have developed a device that is used to identify plaque build-up, and has been designed for use in the home.  It is the size of a toothbrush, and has a blue light that is shone in the mouth.  The viewer looks through yellow glasses with a red filter, and they see any plaque as a red glow.  (New Tool To Improve Oral Hygiene Developed

Researchers have developed a test that tells the likelihood a child will get cavities.  The test works by looking at the relative proportions in saliva of different types of sugar chains, known as oligosaccharides. (USC Dental Researchers Develop First Test For Predicting Cavities In Children)

Researchers have found that they can repair damaged tooth enamel, in the early stages of decay, by soaking teeth in a solution of calcium, phosphate and fluoride, the three substances that make up tooth enamel.  They found that for the mixture to work the ingredients must be combined with the protein casein phosphopeptide at a pH of 5.5.  It’s applied using a custom fit mouth tray, along with a saliva-proof sealing gel.  They expect it to be available for patients in 5 years.  (New treatment could banish dental fillings)

Dental erosion is when the enamel is stripped from your teeth, causing them to become brittle and painful.  It’s caused by acids from such things as soft drinks, sports drinks, herbal teas, some fruit juices, beer salts, Lucas candy, aspirin, acid reflux, and bulimia.  (More U.S. Teeth Susceptible To Silent Enamel-eating Syndrome)  In one study it turned out that, from worst to least damaging drinks, the order was: lemonade, energy drinks, sports drinks, fitness water, ice tea, and cola.  (New Study Indicates That Popular Sports Beverages Cause More Irreversible Damage To Teeth Than Soda)  I would have thought lemonade and other citrus products were healthy, but apparently not totally, and until more is known people are recommending drinking lemonade through a straw, and rinsing or brushing right after drinking it. (Does consuming too much lemon juice cause harm to tooth enamel?) 

I ran across this video (Cure Tooth Pain) that claims you can stop tooth pain with a mixture of mashed garlic, lemon juice, and salt.  One critic was naturally concerned that the lemon acid would destroy the tooth enamel, and recommended oil of cloves instead.  Another person recommended a hot salt water rinse. 

Some dentists are especially concerned about Mountain Dew.  They argue that this drink is worse than others because of its especially high levels of caffeine and sugar.  They have dubbed the blown out mouths they see, “Mountain Dew Mouth.” (Watch what you Dew! Dentists sounding the alarm about heavy soft-drink consumption among teens

It turns out that alkaline substances used in industry can also damage tooth enamel. (Exposure To Alkaline Substances Can Result In Damaged Teeth)  And you are never supposed to hold tacks or nails in your mouth when you are working. 

More than three dozen studies show that dental cavities are not caused by breastfeeding.  It turns out that infant’s cavities are actually caused by a recently discovered type of bacteria, which is called Early Childhood Caries (ECC).  Furthermore, breastfed children are actually less likely to develop this disease than bottle fed children.  ECC correlates with (but is not necessarily caused or caused by): pregnancy complications, traumatic birth, cesarean sections, kidney disease, maternal diabetes, and viral or bacterial infection. For the neonate, risk factors seem to be premature birth, sugary foods, Rh incompatibility, a salty diet, allergies, iron deficiency, gastroenteritis, pacifier use, malnutrition, prenatal exposure to lead, infectious diseases, and chronic diarrhea. (Big Bad Cavities: Breastfeeding Is Not the Cause by Lisa Reagan of The Natural Child Project)

There seems to be no strong research that supports routinely removing disease-free impacted wisdom teeth.  The reasons for this are the difficulty of following a population over 10 to 20 years, and the small number of adults with impacted wisdom teeth, since they are routinely removed.  Of course, this does not mean they shouldn’t be removed, we just don’t know.  (No Wisdom In Routinely Pulling Wisdom Teeth, Study Says)    

Chewing on ice is bad for your teeth because you are subjecting your teeth to a thermal shock when the enamel contracts.  Heat has the opposite thermal shock effect, so drinking hot drinks isn’t ideal either.  And if you have fillings the effect is even worse, since the dental materials will contract or expand differently than the tooth.  It can make for painful teeth, and in the worst case the tooth can fracture. 

If your teeth are sensitive to heat or cold this could also be because you might have a small fracture in a tooth.  Your dentist can test for this possibility.  (Is chewing ICE bad for your teeth?)  

People who have a general sensory sensitivity with their hearing, sight, taste, smell, and touch also very often have sensitive teeth.  Such people avoid loud noises, bright lights, perfumes, itchy clothing, and hot and cold foods. (Wear Sunglasses? You May Have Sensitive Teeth)   

It turns out that a desire to chew ice is one symptom of iron deficiency.  Seith Roberts suggests that one of the few crunchy things in the hunter gatherer days were bones, bone marrow has lots of iron, so this desire evolved because it was adaptive. (Pagophagia and the Umami Hypothesis)  

For those who are hoping for a perfect solution to many dental problems, Japanese scientists have been able to grow a new tooth in a mouse.  They did this by taking two types of cells, mesenchymal and epithelial, separately growing large numbers of them, putting them together into a drop of collagen, growing a tiny tooth, and then inserting it into the mouse’s mouth.  The transplant grew into a perfect new tooth.  (Toothless mice can eat againResearchers have also been able to regrow mouse teeth from tooth buds extracted from mouse embryos, although in this case the teeth were simpler and with fewer facets.  (Teeth regrown for the first time) Inventors claim that they have developed a device that massages gums with pulsed ultrasonic waves that can grow a toot from a tooth root.  They also say that it can also be used to stimulate bone growth.  (Smile! A new Canadian tool can re-grow teeth say inventors, and How to regrow or repair bad teeth naturally

They’ve found mutant chickens with teeth, alligator teeth that is.  The discovery led researchers to speculate that chickens might still have most of the genetic machinery necessary to grow teeth, and they have found that they can induce teeth to grow in normal chickens by changing the expression of certain molecules.  The hope is that this research could one day lead to re-growing teeth in people.  (Mutant Chicken Grows Alligatorlike Teeth)

Since bone loss often causes tooth loss, it seems relevant to mention that scientists have developed an injectable toothpaste-like solution that hardens in the body, and provides a porous biodegradable scaffolding for the formation of new bone.  It works by using a combination of stem cells and growth factors.  (Injectable artificial bone developed)

A research team has developed software that can detect osteoporosis using routine dental x-rays.  The method does this by measuring the thickness of part of the lower jaw.  (Dentists Could Detect Osteoporosis, Automatically)

It’s probably best to avoid getting the Epstein-Barr virus since it has been found to be associated with inflammatory diseases of the mouth. (Epstein-Barr Virus Associated With Inflammatory Diseases Of The Mouth)  

Another oral problem people often have is Halitosis, or bad breath.  (Bad Breath (Halitosis) – ADA)  It can be caused by certain foods, poor dental hygiene, dry mouth, and tobacco products.  It can also be caused by various medical conditions, such as an infection in the respiratory tract, chronic sinusitis, tonsil stones, trimethylaminuria, postnasal drip, chronic bronchitis, diabetes, gastrointestinal disturbance, or a liver or kidney ailment.  If you are on a low carb diet, or fasting, you could develop ketone breath, which happens when ketones build up in your body and are released in the mouth. 

One common piece of advice for managing bad breath is to use a tongue scraper, since bacteria on the back of the tongue is often the source of the problem. (Using a tongue scraper or brush can cure bad breath.)  Other advice is to use a water pick, drink more water, chew gum that is cinnamon flavored and contains xylitol, and to floss. 

Scientists have found that the more oral bacteria you have the higher the risk you have of having a heart attack.  (The More Oral Bacteria, The Higher The Risk Of Heart Attack, Study Shows)  

Besides heart disease there are a number of other conditions associated with poor oral health.  (It’s important to remember that the nature of the relationship in each case might be only correlational, or it might be causal in one direction or the other.  Or it could even be reciprocal.  So, the relationship of each comorbid condition to oral bacteria must be considered separately, although in many of these cases the nature of the relationship is reasonably clear.)   These conditions include Alzheimer’s, premature birth, diabetes, HIV/AIDS, osteoporosis, Sjogren’s syndrome, certain cancers, eating disorders, syphilis, gonorrhea and substance abuse.  (Oral health: A window to your overall health, Diabetes and Oral Health Problems, Dental Health May Influence Alzheimer’s, Gum Disease, Heart Disease, Premature Births, and Vitamin K2 - Lost Wanderer)   

One form of chronic fatigue syndrome (CFS) might be triggered by a rare reaction to dental metals.  In one Swedish study, 76% of CFS patients who tested positive for metal allergy, on the MELISA blood test, and then had their metal fillings replaced, achieved some or full health improvement.  (Further arguing for some sort of allergic like connection with CFS, it might also be caused by gluten intolerance, celiac disease, and chronic sinusitis.) (Encyclopedia – Chronic fatigue syndrome, and Chronic Fatigue Syndrome or Chronic Mercury Poisoning?)  

From GutBuddies – Safe dental anesthesia for helminth hosts, there is a new type of dental anesthesia available for drug sensitive patients that doesn’t involve any needles or medications, because it works by using cold to numb your teeth.  The gumEase G100 is filled with a chilled saline solution, and fitted around your teeth to cool them to -7 degrees C.  Several of the devices used in sequence will work for almost all normal procedures, its 100% pain relief lasts for up to twenty minutes, and it can also be used post-operatively at home.  The device is FDA approved, currently available for dentists to try, and is probably less expensive than regular anesthesia.  (I wonder about any problems this product might create for patients who have cold sensitive teeth.)  

GumEase is also being tested for relief from tension and migraine headaches (Migraine Headaches - Lost Wanderer), and patients who have tried it report it works for these conditions also.  (Study to Determine Efficacy of gumEase cryoanesthesia Mouthpiece in Treating Migraine and Tension-type Headache Pain without Drugs to Begin)

Your can purchase the gumEase G100 from CryoDevices, or Olympic Dental and Medical Devices.  For dental application it’s about $110 for a box of 10, and for migraines a 3 pack costs about $36.  In the UK you can contact George Harrell at gharrell@cryodevices.com.

Researchers have developed a dental device that will automatically deliver a patient’s drugs.  It fits inside two fake molars, and contains the drug, a release valve, sensors, and actuators.  (Molar medication)  

A new medical device, called PediSedate, has been developed to deliver nitrous oxide for dental or medical anesthesia.  It is a toy-like headset that connects to a game such as Nintendo or a CD player, and while the child is playing or listening to music s/he gradually drifts off to sleep.  (PediSedate)

A 2004 study claims that women who have dental x-rays during pregnancy are three times more likely to have a low birth weight baby.  (Dental X-rays Of Pregnant Women Associated With Low-weight Babies)  However, a number of researchers are very skeptical of this result.  (Dental experts fault study linking X-rays to term low birth weight, and Dental x-rays and low birth weight J. Radiol. Prot. 24 (2004) 321–325)

Researchers are testing a natural hormone called relaxin that might make it possible to straighten teeth more quickly, with less pain, and which would prevent relapse.  (Teeth On The Move by Kate Melville) 

Just for fun, Grand Illusions sells strips of plastic that talk to you when you hold one end in your teeth and run your thumb nail down the tape. (Talking Tapes – Grand Illusions)

 

Alzheimer’s

Saturday, August 15th, 2009

In a previous blog I discussed the Cycad Hypothesis of Alzheimer’s, which postulates that excitotoxicity caused by BMAA toxin from cyanobacteria might be the root cause of the disease.  However, there are many other possibilities.

If I had an identical twin who had developed Alzheimer’s, I would consider everything I could think of to prevent it.   The short list would probably include:  I would eat a Paleolithic Diet, intermittently fast, practice good dental hygiene, exercise, take vitamin D supplements, folic acid, omega-3 fats, curcumin, Longevinex, green tea, and resveratrol.  I also would avoid STDs, concussion-risky sports, toxins, radon, electromagnetic fields, heavy cell phone use, and heavy metals. 

Come to think of it, this just sounds a lot like extremely healthy living.  Below are the details:

The disease has an obvious genetic component, since having a family history of Alzheimer’s increases your risk, as does having an identical twin with it (concordance is 59%).

A relatively new theory is that it is a third form of diabetes.  (Alzheimer’s could be diabetes-like illness, study suggests)  It turns out that the brain produces its own insulin.  In Alzheimer’s the brain’s insulin production, as well as its ability to respond to insulin, drops off as the disease becomes more severe.  Brain cells also lose the ability to respond to insulin growth factors, and when rats were treated with related insulin-like growth factors to correct for this lack of response the typical loss of learning and memory was prevented.  Regular diabetes itself is also a risk factor for the disease.

A moderate or severe concussion will roughly double your later risk of Alzheimer’s.  (Study bolsters head injury, Alzheimer’s link)  This is also true of mild repetitive head injuries.  (Fortunately isolated mild concussions don’t seem to increase your risk.) 

Besides avoiding head trauma, having a generally healthy cardiovascular system and avoiding atherosclerosis helps avoid the disease.  Having moderately high cholesterol and a diet higher in saturated fats are risk factors.  Atrial fibrillation makes it 44% more likely you will get it.  Cardiovascular disease increases your risk by 30%.  And if you’ve had a stroke your chances go up by nearly 50%.  Being obese, metabolic syndrome, and smoking during midlife all put you at greater risk.

Researchers suspect that early nutrition, as indicated by various body measurements, might play a role.  Women with short arms have a 50% greater risk, while a longer shin length is protective. 

Various viruses and microbes can worsen your chances.  Viruses in the herpes family (simplex I, Cytomegalovirus V, and simplex VI) are strongly suspected of being causal factors.  One theory holds that the microbe Chlamydia pneumonia might be the main agent responsible.  Lyme disease and Helicobacter pylori bacteria also are both associated with Alzheimer’s.  

A vasectomy might put men at risk for one rare form of dementia, Primary Progressive Aphasia.  

Vitamin D keeps proving its worth, since low levels of vitamin D have been linked to cognitive decline.  (See also Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease)  

The inhaled anesthetics halothane and isoflurane are linked with amyloid beta buildup.  Childhood lead exposure could increase the risk.  Processed food that contains nitrates might be linked to Alzheimer’s, diabetes, and Parkinson’s.  Other possibilities include mercury, aluminum, and zinc exposure, non-wine alcohol consumption, and work related organic solvent exposure.

Although the lines of causation are far from clear, Alzheimer’s correlates with other mental problems.  Being lonely (an active social life is protective), having a history of depression, and having a major psychiatric illness all increase your chances of getting it. 

Additional correlating factors include:  having poor dental health, being exposed to air pollution,  a history of manual work, a family history of Parkinson’s, maternal age at birth, number of pregnancies, (possibly) exposure to low magnetic fields (Qiu et al, 2004) (Occupations with Exposure to Electromagnetic Fields: A Possible Risk Factor for Alzheimer’s Disease, Do Cell Phones Cause Alzheimer’s? By Maggie Spilner), and age.  There have also been concerns about radon’s radioactive daughter products being found in the brains of Alzheimer’s patients at ten times the normal rate. (Alzheimer’s & Parkinson’s – Could the Cause be Radon?)  

In addition to the above list, here are some more controllable factors that people have suggested:  

Exercise has been shown to slow memory loss.

Dietary restriction and intermittent fasting seem to protect against a large variety of diseases, including Alzheimer’s.  (See also Extreme Diet Nixes Alzheimer’s)  A low carbohydrate and high fat diet has been shown to improve Alzheimer’s disease in mice.  In one study drinking fruit and vegetable juices cut risk by 76%.  The Mediterranean diet also seems to be protective.  Although I haven’t seen any studies on it, given all the lines of evidence I’m pointing out in this blog entry, I feel very confident in predicting that The Paleolithic Diet would be protective.

Having proper levels of folic acid reduces your risk by 55%, probably at least in part because of its effect on homocysteine levels.  Curcumin, which is found in the spice turmeric, appears to block amyloid plaques.  Many results suggest that the omega-3 fatty acid DHA is beneficial.  Silica in drinking water might help prevent the disease.  (See also Nature’s Way Silica Gel)  Huge doses of vitamin B3 have been found to stop the progression of Alzheimer’s in mice.  Marijuana has anti-inflammatory effects, and it might limit the memory loss part of it.  There is some speculation that Vitamin K2 could be beneficial.  Vitamin C and E consumption, coffee drinking, resveratrol, huperzine A, and wine consumption all might be somewhat protective.  (Since I am a teetotaler I’d consider using a product like Longevinex, which they claim has red wine’s benefits in a pill, without the alcohol or calories.)

Although it seems a bit extreme to suggest this as a preventive measure, Alzheimer’s does have an inverse association with cancer.  If this is true with those few cancers which are fully curable, and it were possible to somehow induce such a cancer, this suggests an unorthodox treatment option.

Looking in the doctor’s medicine cabinet, non-steroidal anti-inflammatory drugs, statins, antihypertensives (calcium antagonists), and vaccines for diphtheria, tetanus, polio, and the flue all might be protective.

Academic ability is a protective factor which probably indicates that you aren’t as susceptible to the disease.  A Canadian study showed that bilingualism delayed the onset of Alzheimer’s by up to four years.  A lack of schooling and farm upbringing seems to boost your risk.  (Of course, the farm environment suggests the possibility of chemical exposure as an additional risk factor.) 

Researchers are making progress on possible ways to diagnose the disease at earlier stages:

It turns out that the disease manifests tell-tell signs years before it becomes apparent, and that lower levels of abstract reasoning and recall for verbal materials at a young age are good predictors for Alzheimer’s many years later.  One study, the “Nun Study,” has shown that certain aspects of language usage in young adults are 85%-90% accurate in predicting the disease 50 years later.  The rational for focusing on this population of women was that they lived very similar lives; so many possible confounding variables were eliminated.  Researchers found that linguistic features of the essays these women wrote when they were entering the convent, when analyzed properly, were strongly predictive.  They found that grammatical complexity tells how well a person’s memory is functioning, and “Idea density,” which is the number of discrete ideas per 10 written words, predicts educational level, vocabulary, and general knowledge.  It turns out that idea density at a young age is very predictive of Alzheimer’s in old age.   

Researchers have found that normally people do better on a memory test if the words to be remembered are semantically related.  But people who later develop Alzheimer’s don’t do any better at such tasks, suggesting that they no longer have access to deeper semantic meanings.  The same scientists have also found that implicit memory tests are good for diagnosing Alzheimer’s in its early stages.  In one test, participants were required to read words from a computer screen as quickly as possible.  For healthy people if a word is repeated they will be primed and perform better.  This effect doesn’t tend to happen with people who will later develop Alzheimer’s, indicating they aren’t learning implicitly (learning without the awareness of learning, or being primed) when they perform a task.   

Researchers have developed a technique that allows them to image beta amyloid plaques in living mice.  They did this by using a non-toxic compound that binds to the plaques, which is then visible when scanned by using MRI.  It might turn out not be necessary to go to such lengths, because researchers have discovered that beta amyloid proteins also build up in the eye lenses of patients.  It therefor seems likely that a simple eye test will someday be available for the disease.  Some researchers speculate that it might be possible to develop a saliva test which would be able to detect Alzheimer’s.

As for what medicine might eventually have to offer:

British scientists claim that an experimental drug called Rember, which attacks the tangles that form during the disease, can reduce Alzheimer’s progression by about 80%.   In a small study, the anti-inflammatory arthritis drug Etanercept demonstrated remarkable benefits in patients.  Researchers are now testing a patch which delivers a vaccine that causes the immune system to break down beta Amyloid proteins.  If used early in the disease, the epilepsy drug Valproic Acid (VPA) has been shown to reverse memory loss, by inhibiting the production of these proteins.  A drug tested in the UK and Singapore, Methylthioninium chloride (MTC), blocks the accumulation of tau tangles inside brain cells, and slows the progress of the disease by 81%.  Dimebon, a Russian antihistamine, which seems to improve the functioning of mitochondria, stabilized Alzheimer’s in an 18 month study.  In Australia they have developed a drug PBT2 that attacks plaques.  Exelon, a cholinesterase inhibitor, seems to delay development of the disorder.  Researchers have found that they can increase the expression in the brain of the protein transthyretin, which seems to halt the progression of the disease.

Getting further into what sounds like science fiction, there is an experimental helmet which bathes the brain with infra-red light, which it is claimed stimulates the growth of brain cells and could reverse Alzheimer’s symptoms.  Finally, researchers have been experimenting with trepanation, drilling a hole in your head, on the theory that this increases cranial compliance.  This is the elasticity of the brain’s vascular system, and the theory is that increasing this will in turn increase blood flow to the brain. 

Here is an on-line article by William R. Ware that discusses many of the suspected causes that might be involved, in addition to the ones I have listed, they include: emotional stress, oxidative stress, vitamin deficiency, vitamin b12 deficiency, hypotension, hypertension, alcohol abuse, pesticides, and herbicides, low antioxidant levels, and a tendency for thrombosis.  (See also memory and cholesterol, low levels of cholesterol)  He also reviews the relative risk reduction of a number of drugs currently used to treat Alzheimer’s.  What the more successful drugs seem to have in common is antiangiogenic activity, or the inhibition of new vascularization.  Natural compounds which might have antiangiogenic activity include Omega-6 fatty acids, green tea, licorice, quercetin, squalamine, and shark cartilage.

Here are two positively reviewed books:  The Alzheimer’s Answer: Reduce Your Risk and Keep Your Brain Healthy by Marwan Sabbagh, which, at 330 pages, covers a lot of material; and Beyond Alzheimer’s: How to Avoid the Modern Epidemic of Dementia (Hardcover) by Scott D. Mendelson (See also: Beyond alzheimer’s – summary)

Finally, The Myth of Alzheimer’s: What You Aren’t Being Told About Today’s Most Dreaded Diagnosis by Peter J. Whitehouse provides a contrarian view of the disease.

Gum Disease, Heart Disease, Premature Births, and Vitamin K2

Saturday, August 8th, 2009

Gum disease is a risk factor for heart disease and stroke, and there are several theories  about why this is the case.  The first theory is that it creates a general chronic inflammatory response throughout a person’s body, and the second is that bacteria escape from the gums into the bloodstream infecting the arteries.   Researchers also say that gum infections might be responsible for up to 18% of premature births.

Here is a fascinating write up from Free the Animal about vitamin K2 regarding its effects on dental health:

“And what of my experience? Well, the K2 is the only one I definitely “feel.” Marked difference in softness of skin overnight, and my wife has since noticed her skin improve as well. Within a few days, all plaque deposits on my teeth dissolved and have not returned. This has been a big issue, as I had gum disease and two surgeries about seven years ago. Since getting off grains (probably the gluten) my gum disease has reversed completely according to the dentist. And now, my teeth are virtually always smooth. I rarely feel the need to brush them….(snip) . Price used the combination of high-vitamin cod liver oil and high-Activator X (vitamin K2)butter oil as the cornerstone of his protocol for reversing dental caries. This protocol not only stopped the progression of tooth decay, but completely reversed it without the need for oral surgery by causing the dentin to grow and remineralize, sealing what were once active caries with a glassy finish. One 14-year-old girl completely healed 42 open cavities in 24 teeth by taking capsules of the high-vitamin cod liver oil and Activator X concentrate three times a day for seven months.”

After reading the above, if you still plan on using a toothbrush, a report from the UK says that manual toothbrushes are just as good as electric ones for reducing plaque and gum disease.

Dissolve Tartar with Periogen

Thursday, July 30th, 2009

Periogen is a product which is supposed to dissolve tartar.  I ran across a strong recommendation for Periogen at Xenophilia (True Strange Stuff).  The Author says that he avoided ”two painful and expensive dental procedures” by using it.  The company claims to have a patented formula that dissolves the binding cement that holds the tartar together.  Unfortunately I’ve been unable to confirm this product works as advertised.  The product is new, and there doesn’t seem to be any independent reviews of it online I have confidence in.  I’m going to wait and see how this pans out.

Xylitol

Tuesday, July 21st, 2009

Xylitol is a natural sugar found in fruits that has been shown to decrease cavities by changing the types of bacteria that grow in your mouth.  It has a glycemic index of 7, so it is safe for diabetics and hypoglycemics.  In taste tests it does well, and is the sugar used in “sugarless” gum.  The only downsides that I know of are its cost, that large amounts of it can cause diarrhea and gas, and the fact that it’s very bad for your dog if he eats it.  Sucrose on the other hand has a host of bad health effects for us.  For more information here is the Wikipedia article on Xylitol.  Iherb.com sells Xylitol, and I have found them to be an excellent and inexpensive source of health supplements.

Vitamin K2

Thursday, July 16th, 2009

In the early 20th century Dr. Weston Price attempted to solve the riddle of the terrible dental health he found in his patients in Cleveland by traveling to other non-western “primitive” societies looking for an answer.   What he found was many societies with remarkable levels of dental health, people with few cavities, and straight teeth because they had wide handsome jaw lines.   At the time he published his results both in peer reviewed journals, and later in his book Nutrition and Physical Degeneration.  While he was able to identify which foods it was found in, he never did discover the substance that he called “Activator X”, which made the difference.

In 2008 the Weston Price Foundation published a lengthy report by Chris Masterjohn solving the mystery.  It identifies vitamin K2 as Activator X, which he says is important for mineral utilization, proper growth, brain functions, and the prevention of dental carries and heart disease.   In modern society we are deficient in it because, while our bodies do convert the vitamin K1 in vitamin pills into K2, they do it inefficiently.  While in nature the best sources of K2 are grass fed animal fats and fermented foods, our meat comes from grain fed animals, so it contains little K2.  

Stephan Guyenet at his Whole Health Source blog writes about K2, and cites a study which looked at heart attack risk in Dutch men that concluded  that those getting the most K2 in their diets had a 51% lower heart mortality.   He also points out that Thorne Research makes a convenient K2 supplement in liquid form.  Also, this site about K2 provides information concerning how much a person should take.