Posts Tagged ‘Vitamin D’

Preventing Falls

Saturday, November 28th, 2009

Falls are the second leading cause of accidental death in the United States each year.  According to the home safety council they cause about 5.1 million injuries and nearly 6,000 deaths yearly.  (Falls Prevention - Home Safety Council)  Many seniors who fall never go home again, and are placed in care facilities or end up in a wheelchair for the remainder of their life.  The average cost of health care resulting from a fall is $19,440, not including doctor’s fees.  Falls also result in five times more hospitalizations for seniors than the next leading cause.  Roughly 25% of such falls are listed as the main cause of death through complications in those over 65 years of age.  (Cost of Falls Among Older Adults – CDC) (Hip Fractures Among Older Adults - CDC

Here are some ways to prevent them:

The stairs are where many serious falls occur, and a large number of them occur when someone is carrying something.  So, don’t try to carry too many things at once, and give yourself at least one free hand to grab the handrail.  You should have secure handrails on both sides of your steps and stairs, and make sure they run from the top to the bottom extending 12 inches beyond both.  They should be rounded and no more than 1 & 1/2 inches in circumference.  Their ends should also be shaped to indicate when you have reached the top or bottom.  Obviously, keep all litter off stairs.  The entire stair length should be well lit, and you should be able to turn on the lights from both ends.  Preferably stairs should have no carpet, but instead anti-slip strips or anti-slip paint on them.   If there is carpet on the stairs it must be firmly attached and be tightly woven with a low pile.  Your stairs should not have noses or open risers.  If there are children in the home the stairs should have safety gates.  Stair treads should be deep enough for a whole foot, 11 inches or more.  Stair rises should be no higher than 7 inches.  If you have eye problems you should paint a line at the edge of stairs so you can see it better.  The ultimate stairs solutions would be either to live in a house with only one level, or to install an elevator.  If you have only a short rise to deal with consider having a ramp instead of steps. 

The bathroom is another common place where falls occur.  You should have non-slip strips or a mat in the tub or shower.  You should also have a non-slip bath mat outside of them.   Have grab bars in them, and handle bars on the toilet that makes it easier to stand up. (1)  All grab bars must be mounted properly, so they can not only carry a person’s full weight, but also the greater momentary force generated when a person is falling.  Replace a sliding glass door with a shower curtain.  A shower seat will allow people to wash without having to bend over.  A liquid soap dispenser will prevent having to fish around for a dropped bar.  And a storage unit attached to the shower or tub will reduce a person’s need to turn around to reach things.  You can convert your regular shower head to a hand held shower spray, which will allow you to reach farther.  If you buy a tub transfer bench you can remain seated at all times when getting in and out.  You also might consider converting over to a walk-in shower.  Fix any leaks which might make the floor unnecessarily wet and slippery.  Remove soap build-up in tub or shower on a regular basis.  Use hard water, since soft-water can make things very slippery.     If you need to go to the bathroom often at night, consider using a bedside commode.  

In the kitchen you should install cabinets, sliding shelve, and lazy Susans so that you don’t have to reach up to get things.  Commonly used items should be stored between waist and shoulder level.  To reach higher items have a solid step stool with nonskid steps and feet and a bracing bar to hold on to.  Wipe up spills as soon as they happen.  The oven and refrigerator should open easily.  You should have an area where you can sit down to prepare food.  Use non-skid wax on the kitchen floor, and put a non-skid mat by the kitchen sink. 

Around the home make sure that cords are not underfoot, and don’t run them under rugs directly where you walk.  You should have a straight path through every room.  Floors should be smooth and level, but not slippery.  Preferably doorways should be wide, 36 inches is a good size.  All doors and windows should open and close easily.  Living room chairs should be sturdy, not swivel chairs, chairs on casters, or lightweight chairs.  All the other furniture should also be sturdy enough for you to lean on.  Carry things in your pockets so your hands are free to grab and stop a fall.  Don’t walk in the dark, but have night lights in the bedroom, hall, and bathroom.  Glowing light switches can help.  Make sure your lighting doesn’t produce hazardous shadows or glare, and light cords should be long enough so you don’t have to reach up.  Provide good lighting for the closet.  Carry a small flashlight on your keychain.  Ideally get rid of small rugs, or, if not, at least securely tape them to the floor with double sided carpet tape all around.  Repair or replace frayed corners or rolled up edges on carpets and floor coverings.  In general you want to minimize bending or climbing.  A long-handled grasper can be used to reach objects that are on high shelves or on the floor.  Lower the closet shelves.  You should get up from chairs or your bed slowly, and take advantage of the fact that higher chairs and couches are easier to ease into and out of.  Keep track of where your pets are, and put them in another room before carrying heavy things into the house.  Close cabinets and drawers when done.  Have a phone close to the floor so you won’t have to get up in case you fall, and keep emergency numbers near each phone.   Furniture should have rounded or padded corners in case you fall. (Safety Edge & Corner Guards)   

In the bedroom your bed should be low enough such that you do not have to climb into it, and high enough so that you can sit with your feet on the ground.  Have the light switch and your eyeglasses within arm’s reach of where you sleep, and a phone close to the bed so you can answer it from there.

Don’t wear trailing clothes, and if your clothes have long cords shorten them.  Avoid bare socks, smooth soled shoes, shoes with shoelaces, and slippers.  Instead wear low heeled shoes with good grip, or go barefoot.  If you are barefoot you will feel the ground better, and this feedback should help you walk better.  (See also: Barefoot Walking and Running – Lost Wanderer)  Matt Metzgar reports on a high tech approach that works along these lines.  Researchers are doing vibration research that involves providing sensory feedback to people’s feet.  Scientists at Harvard are working on vibrating insoles, and one group has shown that such subsensory vibrations do improve the elderly’s gait. (Vibration Roundup – Matt MetzgarStatipro (a French company), US Patent 6024093 – Proprioceptive sole or pedal device containing crystals for treatment of statural disorders, Vibrating Insoles – Wyss Institute, and Subsensory vibrations to the feet reduce gait variability in elderly fallers)     

Outside you need a roof or awning to keep snow off of your home’s entrance-way.  Have a place near your door where you can put packages while you close it and get ready to put things away.  Sidewalks and walkways should be well lit and clear of debris, clutter, and weeds.  You should keep your steps and sidewalks in good condition by fixing broken or uneven steps.  Holes and cracks are trip hazards, as are bumps and ridges.  Put abrasive strips on outdoor steps, and have a non-stick surface area inside all of your outside entrances.  Install motion sensitive lights on your outdoor paths.   Have someone shovel immediately after a snow storm, and then apply salt or sand.  All entrance areas should have an outside space large enough such that you are not crowded by your swinging door.

To prevent child falls consider installing window guards on windows ground floor and up, unless designated as emergency fire exits.  Make sure they have easy release mechanisms.  When a child can pull to a standing position, the crib mattress should be adjusted to its lowest position; there should be at least 26 inches between the top rails of the crib drop side and the mattress.  Toys, bumper pads, and other objects that can be used as steps to climb out should be removed from the crib.  Never leave babies alone on beds, changing tables, or sofas.  Strap children into high chairs and strollers.  Keep furniture away from windows.  Keep windows and doors locked.  For bunk beds you should never allow a child younger than age 6 to sleep on the top bunk.  For older children, if the upper bunk is not up against a wall, use guardrails on both sides.  No matter how old a child is, keep the guardrails in place on the top bunk since children might roll out during sleep.  Don’t allow any horseplay on bunks.  You should keep dresser drawers pushed all the way in to lessen the risk of a child climbing up the dresser.  Make it a habit to push kitchen and dining room chairs in under the table to take away an attractive climbing gym for children. Don’t store desserts or other treats in high locations, particularly over stoves, to decrease climbing temptations.  Outside, ladders should be put away and hung on their sides when not in use.  Playgrounds should have 12 inches of padding.

Certain situations increase the risk of falling.  You should be careful when you are on a stool or ladder in reaching your arms out or overextending your reach.  Are there situations where you have to rush, such as getting to the front door, or answering the telephone?  Think of ways to eliminate these situations.  Slow down, take your time.  Also, be careful about consuming alcohol.

One major risk factor to keep in mind is that vitamin D deficiency is very common and can lead to abnormal gait, muscle weakness, osteomalacia, and osteoporosis.  (Vitamin D Deficiency in Modern Society – Lost Wanderer)

Other things that increase your risk of include having a history of falls, age, living alone, and being Caucasian.

Medications that can increase the risk include benzodazepine digoxin, diuretics, sedative psychotropics, taking four or more medications, and class 1a anti-arrhythmic medications. 

Medical conditions that increase your risk of falling include circulatory disease, poor nutrition or malnutrition, poor postural performance, impaired cognition such as with dementia or memory problems, visual impairments, muscle weakness (indicated in particular by having a slower walk and poor hand strength), a history of stroke, a low body mass index, poor self-rated health and decreased quality of life, chronic obstructive pulmonary disease, depression, arthritis, thyroid problems, incontinence (which leads to frequent bathroom trips at night), impaired mobility, drowsiness, dizziness, poor balance, low blood pressure, Parkinson’s disease, Meniere’s disease (affects the middle ear and causes vertigo), poorly controlled epilepsy, joint stiffness, limited neck movement, any lower extremity disability (loss of strength, orthopaedic abnormality, foot problems, or poor sensation), and difficulty in rising from a chair.  Fear of falling can also lead to falling because people who are afraid of falling will restrict their physical activities and become sedentary.

There are many health related preventive steps you can take to help prevent falling.  Get your vitamin D level checked.  You should regularly get your eyes and hearing tested.  If you have foot problems get them treated. You should exercise, for example take Tai Chi Lessons, and perhaps even learn better how to fall.  Work on increasing your balance, strength, cardiovascular capacity, and flexibility.  Review your medications (including supplements and other products you take over-the-counter) with your doctor.   

Assistive devices can be very helpful in preventing and coping with falls.  If your doctor recommends a walker or cane for stability, learn how to use it properly from a health care professional, and then do use it.  Some people use hip protectors, or get an alarm device they wear in case they fall.  There are a number of other assistive devices, mobility aids, and other helpful gadgets available.  (Arthritis Aids – Gadgets – Products – Tools – Adaptive Equipment  Keep all such devices in good repair. (replace worn rubber tips, etc.)  During winter cleats for your shoes and boots can be helpful for dealing with ice.  (Polar Cleats) (Get-A-Grip Advanced – Snow & Ice Traction Cleats)

If you do fall you should try to fall on your side or buttocks, rolling over naturally turning your head in the direction of the fall, and keep your arms bent.  Don’t necessarily try to get up right away, but assess the situation, and then, if the situation suggests it, crawl to find something to raise yourself up with. 

(1)  A raised toilet seat will also make it easier to get up.  But, on this issue there is a trade-off, since using a squat toilet is the natural and healthier way for you to do your business.  (The Squat Toilet – Lost Wanderer)  For someone who has a condition such as arthritis, I have read that in Asia they make a squat toilet that starts out in sitting position and then mechanically lowers you into position.

(Practical Guide to Universal Home Design: Convenience, Ease, and Livability – Remodeling, Building, and Buying a Home) (Preventing Slips and Falls) (Prevention of Slips, Trips and Falls) (The Fall Prevention Project) (Preventing Falls in the Home – NAMIC Online) (A Home Fall Prevention Checklist for Older Adults – MetLife) (Minnesota SeniorSafe – Minnesota Safety Council) (Fall Prevention Home Safety Checklist What YOU Can Do To Prevent Falls – Minnesota Safety Council) (Preventing Falls at Home)(Home Fall Prevention Guidelines) (Preventing Injuries from Slips, Trips and Falls) (Preventing Falls: How to Develop Community-based Fall Prevention Programs for Older Adults - CDC) (What Causes Falls in the Elderly? How Can I Prevent a Fall?) (Preventing Falls in the Elderly by K.R. Tremblay Jr., and C.E. Barber1 (12/05) (What are the main risk factors for falls amongst older people and what are the most effective interventions to prevent these falls? -  World Health Organization – Europe) (Aging well: Making your home fall-proof – CIGNA) (Handicap Shower Safety – 10 Money Saving Keys to Fall Proof Your Shower Area – No Tools Required! – Ezine Articles) (How to Fall-Proof a Bathroom for Seniors – Denise Wang) (Fall-proof your home – Humana) (Tumble-Proof Your Home to Prevent Falls – Common sense precautions for all ages By Sandra Wendel) (Fall Prevention Center of Excellence) (Preventing Slip-and-Fall Accidents) (Fall Prevention Center) (CDC – Falls – Older Adults) (What you can do) (Preventing Falls) (Preventing Injuries from Slips Trips and Falls – NASD) (Public Enemy Number One: Slips, Trips and Falls) (Falls – Older Adults – Home & Recreational Safety - CDC) (Falls Among Older Adults: An Overview – Home & Recreational Safety – CDC) (Falls in Nursing Homes – CDC)(Fall Prevention Activities – CDC) (Preventing Falls: What Works – CDC) (Help Older Adults Live Better, Longer: Prevent Falls and Traumatic Brain Injuries - Public Health Grand Rounds) (Podcasts — Unintentional Injury Prevention – CDC) (Causes of Falls – Wrong Diagnosis) (Causes of Falls – Osteoporosis-INFO.com) (Preventing Falls Among Older Adults – Patricia M. Burbank) (Pets cause falling injuries – Wellsphere) (Creating a Fall Proof Environment in Your Home - National Safety Council) (Safety First: Fall Risks and Fall Prevention Tips – parentgiving) (Be Safe at Home – Minnesota Falls Prevention) (Falls – Older Adults - CDC)

 
 

Carbon Monoxide

Friday, November 20th, 2009

Carbon monoxide (CO) is the leading cause of poisoning worldwide, with it killing and injuring more people than all other poisons combined. (Carbon Monoxide Protection) It is colorless and odorless, becomes toxic at 25 ppm (parts per million), and deadly at 400 ppm.  The early symptoms of CO poisoning often mimic the flu, causing headaches, nausea, unclear thinking, shortness of breath, weakness, and loss of muscle control.  CO accounts for about 40,000 known cases of poisoning in the U.S. each year, and in about 500 of these cases the person dies.  Some experts estimate that about 11,000 undetected cases occur each year, and because of this have recommended routine emergency room screening for CO poisoning. (Routine Screenings Uncover Hidden Carbon Monoxide Poisoning)  

In about half of the most serious cases where people do survive they will later develop permanent brain damage.  Now researchers know part of the reason why; in about half of the cases of permanent brain damage (so for a total of a quarter of the most serious cases where the people survive) it’s an autoimmune reaction.  CO alters some of the brain’s myelin in such a way that a person’s immune system attacks it, then doesn’t know when to stop, and goes after much of the rest of the brain’s myelin.  (Long-term Effects Of Carbon Monoxide Poisoning Are An Autoimmune Reaction)  (GAS ATTACK: Carbon Monoxide Poisoning

If that wasn’t bad enough, CO harms people in a number of other ways.  It can permanently damage a person’s heart, independently of its role in oxygen deprivation.  (Carbon Monoxide May Cause Long-lasting Heart Damage)  The fetus is particularly vulnerable to it, down to levels as low as 25 ppm.  (Tiny Levels Of Carbon Monoxide Damage Fetal Brain)  Children and infants might suffer hearing damage at these same levels. (How chronic exposure to tiny levels of carbon monoxide damages hearing in young ears)  Also the probability of hearing damage goes up if noise and carbon monoxide are combined. (Noise And Carbon Monoxide Exposure Increases Hearing Loss In Workers According To Université De Montréal Study

Here is a laundry list of things to do to avoid killing yourself with CO:

Have at least one CO detector in your home outside each sleeping area, and in your workplace.  Make sure they’re working.  If one goes off get out and call 911.  (Know About CO - Alarm Education) (The Silent Killer: Selecting an Effective Carbon Monoxide Detector that can Save Lives)  (AlarmSuperStore.com)

Have your gas or oil furnace, wood stove, fireplace, gasoline powered generator, gas water heater, gas oven, gas dryer, kerosene and gas space heaters, stove and any other gas, oil, wood, or coal burning appliances serviced by a qualified technician every year. 

All gas appliances must be vented, with a pipe that is somewhat vertical and not perfectly horizontal.  Always properly patch a vent pipe.  Only buy gas equipment that is certified by the AGA or UL. 

Your gas oven should have an exhaust fan, and also never heat your house with your oven.

Don’t use a generator, camp stove, kerosene heater, charcoal or gas grill, portable flameless chemical heater (catalytic) in your home, garage, or even outside near a window.  You should never burn charcoal indoors. (Portable Heater and Generator Safety) (Unvented Portable Kerosene Heaters – Safety Considerations)

Don’t run a car inside a garage, especially if it is attached to your house.  Have your car’s exhaust system checked every year.  If you have a vehicle with a tailgate, if you open it you must open the vents and windows to move air through your car or truck.  Be very careful about letting people ride in the back of an enclosed pickup truck.

Don’t use any gasoline powered engines such as mowers, snow blowers, chain saws, weed trimmers, generators, or small engines in enclosed spaces.  A propane or charcoal barbecue should only be used outdoors away from any buildings. 

If your refrigerator’s cooling unit gives off an odor have it checked, it could be giving off CO.

Spray paint, solvents, degreasers, paint removers, and cigarette smoke are all sources of CO.

It can be dangerous to swim near a boat’s stern when the engine is running.  You shouldn’t moor next to a boat that is running its engine or a generator.  Your boat should also have a CO detector. (Carbon Monoxide Poisoning Causes) (Boating and Boat Safety: Reduce the Odds of Carbon Monoxide Poisoning)

When you are traveling you should remember that there is no federal law that requires CO detectors in hotels, and about 50 people a year are poisoned in them.  (Hotel Guests At Risk From Carbon Monoxide Poisoning, According To Study)  Some people recommend traveling with a portable CO detector, and one such model is the Costar P-1.  (How to Ensure your Safety against Carbon Monoxide Poisoning in Hotels)

CO poisonings sometimes occur after a disaster when people are using emergency generators. (CDC – Carbon Monoxide Poisoning After a Disaster)

Doctors recommend that you seek prompt medical attention if you suspect CO poisoning and are feeling dizzy, light-headed, or nauseous. 

One positive step is that researchers have developed a new method for clearing carbon monoxide from a person.  Instead of using 100% oxygen they used a mixture of oxygen and carbon dioxide, which cleared CO three times faster.  (Simple New Method Holds Great Promise For Treating Carbon Monoxide Poisoning Quickly And Easily)

Another interesting wrinkle in the CO story is “that paranormal experiences track quite closely with symptoms of carbon monoxide poisoning.” (From a reader’s comment on Haunted Houses Possibly Explained – Lost Wanderer) (Carbon monoxide as an explanation for perceived hauntings – Haunted house – Wikipedia)

Having said all this, doctors are finding that CO can be useful in some circumstances.  It turns out that a little CO can be beneficial in treating pre-eclampsia. (When Preventing Pre-eclampsia, A Little Carbon Monoxide Goes A Long Way)  (However, I think a safer and more natural alternative might be vitamin D supplementation. (Vitamin D for the Prevention of Preeclampsia?  A Hypothesis.))  And CO is an anti-inflammatory that could be useful in treating certain lung diseases, multiple sclerosis, and other inflammatory conditions. (Carbon monoxide could fight disease and Carbon monoxide may protect against MS symptoms)  

Finally, here are some general overviews of CO related information and CO poisoning. (Carbon monoxide poisoning – Wikipedia) (An Introduction to Indoor Air Quality – Carbon Monoxide (CO))

Schizophrenia

Wednesday, October 14th, 2009

The short list of things I would do to try to prevent schizophrenia will sound very familiar to anyone who reads this blog:  Both the future mother and offspring should get lots of vitamin D, should be on a Paleolithic Diet, have hookworms and whipworms, get plenty of sleep, have a good family, and live in a close community.  They should not be exposed to lead, should have low stress, no X-rays, and be of high status.  Neither of them should be exposed to the flu, toxoplasmosis, the Borna virus, rubella, cytomegalovirus, herpes simplex 2, and syphilis.  They also should avoid tobacco, cannabis, and other illegal drugs.  Also, the father should not be old. 

For a more detailed discussion you can read the rest of this blog entry:    

A diagnosis of schizophrenia is made on the basis of a patient’s symptoms, since there is no laboratory test for it.  Because of this, there is every likelihood that it is actually a cluster of conditions, each with a different etiology.  One school of thought even argues that we should diagnose people in terms of a series of dimensional continuums, instead of having a cut off for a diagnostic category.  Perhaps partly because of the uncertainties involved there many theories about schizophrenia’s ultimate cause.

Before I get to the more mainstream perspectives, I want to touch on the viewpoint of Thomas Szasz.  He’s skeptical of the whole medical model, and argues that schizophrenics have a legitimate way of looking at the world, are simply making people uncomfortable, and that society doesn’t have the right to control people for this reason alone.  (His position is closely related to the reasonable insight that cultural differences influence the rates of diagnosis, and that different cultures have different ways of dealing with the various forms of what we would call mental illnesses.)

My response to Szasz is to say that it isn’t true that schizophrenics are only making people uncomfortable, but that there are potentially lethal consequences in allowing someone who is delusional behind the wheel of a car.  Even if it were the case that schizophrenics universally had no complaints regarding their condition (which, in fact, isn’t true), I think that society should have the right to protect itself from the likely consequences of these people’s, so called, “different equally legitimate patterns of thought,” and in many circumstances it should be able to do so whether or not the schizophrenic agrees.  And, while we’re at it,  if others have to pay the bill for their maintenance, then those who have to work to support them should also have a say in their getting treatment.  If Szasz can show me the hard data that proves that schizophrenics are able to function perfectly well by living up the responsibilities of supporting themselves, of being responsible capable citizens, and they are happy with their condition then I might agree that we should drop the whole concept from the DSM.  But until then, I’m going to see it as a problem. (Schizophrenia – Schizophrenia as a social construct – Wikipedia

Szasz also argues that schizophrenia is simply a social construct, and as such doesn’t actually exist.  It’s true that we pick out those aspects of the world we find important, and package them into the concepts of our languages.  But the world imposes itself upon us, and so it is, at best, misleading to say that by doing so we are engaged in “constructing reality,” as opposed to responding to and taxonomizing it.  Using similar reasoning people have argued that gender doesn’t actually exist either.  (See: Deconstructionism is Horsesh*t – Lost Wanderer)       

Traveling further into la la land, in 1976, Julian Jaynes speculated that schizophrenia was the normal operation of the human mind until fairly recently.  Supposedly, up until about 3,000 years ago, people went around with minimal self awareness much of the time, and every now and then they would hallucinate, and “the Gods” would speak to them, which was actually their verbal left hemisphere sending them a message.  Civilization’s beginning marked the beginning of what we currently call normal self consciousness.  Jaynes’ ideas, like Szasz’s, don’t pass the giggle test, and strike me simply as an example of what has been called “fashionable nonsense,” since no one has ever reported any such observations with hunter gatherer peoples.  (The Legacy of Julian Jaynes by Dan Hartwig) (See also: Schizophrenia – Other proposed causes - Wikipedia)

Moving away from la la land, one theory is that schizophrenia is the price we pay for our large brains’ energy demands.  (Are big brains to blame for schizophrenia?)  Or perhaps it’s the result of our left brain specializing in language.  (Schizophrenia as failure of hemispheric dominance for language by TJ Crow) 

There are many genes which contribute to schizophrenia, (Schizophrenia Risk Gets More Complex) overlapping those that code for manic depression, (Unlocked: the secrets of schizophrenia by Steve Connor) and the fact that schizophrenics have low fecundity raises the question of why the genes that increase its incidence haven’t been selected out.  It could be that there are major advantages to having them, however currently there is no good theory as to what these might be.  It could also be that it’s a recent phenomenon arising out of some change in the relevant triggering environmental factors.  If this idea proves to be correct, it would mean that schizophrenia can be added to the long list of “Diseases of Civilization.”

A very credible candidate as a major cause of the disease is vitamin D deficiency.  John Cannell, of the vitamin D council, makes the case for this by pointing out such facts as the incidence of schizophrenia is much higher in people with dark skin who live at northern latitudes, and there is a 10 fold variance in the rate of schizophrenia that also follows the lines of latitude.  (Vitamin D and Schizophrenia)  Also, in a Finnish cohort study, vitamin D supplementation of at least 2,000 IU/day during a child’s first year was associated with a lower rate of the disease.  (Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study)  Vitamin D might explain the fact that schizophrenia varies by the season of a child’s birth. (Relative Risk for Schizophrenia depending upon Month of Birth)  And one route through which Vitamin D could be acting is through its neuroprotective role in cleansing the body of heavy metals, such as lead. (See below) (Vitamin D protective against toxins – Vitamin D and Schizophrenia)

Another candidate cause is milk protein.  In one study 95% of autistic and schizophrenic children had 100 times the normal levels of milk protein in their blood and urine, and 80% of them had their symptoms resolve when they were put on a milk free diet.  (University of Florida Researchers Cite Possible Link Between Autism, Schizophrenia and Diet)

There is some evidence that gluten is the problem for a subset of patients.  (Schizophrenia – Alternative Medical Treatments – Wikipedia and Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature)  Consistent with this, the Specific Carbohydrate Diet (SCD), which restricts complex carbohydrates and eliminates sugar, has been promoted for a wide variety of diseases, including schizophrenia.  (Specific Carbohydrate Diet – Wikipedia and Everything about The Specific Carbohydrate Diet totally explained)  (The SCD has much in common with the Paleolithic Diet (PD).  However, the PD allows tubers, and doesn’t allow cheese, yogurt, and legumes. (Everything about Paleolithic Diet totally explained and The Paleo Diet))

In the Dutch Famine Study, prenatal nutritional deprivation during the second trimester was found to double the rate of schizophrenia. (Dutch famine of 1944 - Wikipedia and Prenatal Risk Factors in Schizophrenia

Catching the flu in the first half of pregnancy leads to a 3-fold increase in the incidence of the disease, and if a women contracts this disease in the first 13 weeks the risk goes up 7-fold.  Although the nature of why this relationship exists isn’t clear, researchers estimate that 14% of cases might be linked to the flu in this way.  (Womb flu link to schizophrenia)  (See also: Coughs and sneezes spread mind diseases

Another infections organism that might lead to the disease is toxoplasmosis. (Toxoplasmosis Parasite May Trigger Schizophrenia And Bipolar Disorders)  The Borna virus might play a role (Borna Virus by Sean Henahan), as well as catching rubella or cytomegalovirus (a 17-fold risk increase) before age 12. (Prenatal Infection as a Risk Factor for Schizophrenia by Alan S. Brown and Childhood brain infections risk of schizophrenia )  Also, herpes simplex virus 2 (HVS-2) might be a risk factor. (Mother’s Herpes Virus Infection Associated With Schizophrenia In Her Offspring, Hopkins Researcher Finds).  When syphilis became treatable thousands of schizophrenics were cured. (Diseases of the Mind by Janet Ginsburg)  Some researchers believe that schizophrenia is caused by ancient viral DNA that became incorporated into our genome, which then becomes reactivated. (Is schizophrenia caused by an enemy within? by Joanna Marchant)  (See also: Plague Time by Paul Ewald)

A mother’s stress can be a contributing factor.  Looking at a cohort of Israeli children, who were in their second month of gestation during the 1967 Arab-Israeli conflict, for girls there was a 4-fold increase in schizophrenia later in life.  And when researchers looked at the mothers who had been subject to the worst stress of direct shelling they found a 30-fold increase.  (Early pregnancy trauma boosts schizophrenia risk)     

The children of older fathers suffer a slight reduction in IQ (2 points), and are at higher risk for such disorders as schizophrenia (50% more likely), autism and bipolar disorder.  (Children of older dads pay IQ price and Father’s age linked to schizophrenia risk)

Another factor that might increase the rate of schizophrenia is prenatal X-rays.  (X-Ray Radiation during Pregnancy & Early Childhood may increase risk of schizophrenia for child)

Perinatal traumatic events such as obstetric complications have been associated with schizophrenia in retrospective studies, however in the only prospective study done to date no such association was found.  (Prenatal Risk Factors in Schizophrenia by Alan S. Brown)

The use of cannabis and cigarette tobacco is associated with the disease.  Especially in this case I have to wonder about whether this is a causal relationship, or merely the case that those with the condition are more likely to use these products.  (Cannabis Increases Risk Of Psychosis and Brain Disorders, Smoking and Nicotine Addiction – Report Summary (March, 2006))  (See also: Psychiatric epidemiology: searching for the causes of mental disorders  by Ezra S. Susser) 

The same question can be raised about schizophrenia’s association with parental absence during early childhood (Causes of schizophrenia by Stephe Ellis and Children at risk for schizophrenia: a longitudinal perspective By Norman F. Watt), child abuse (Child Abuse can Cause Schizophrenia by Rick Nauert), living in an urban environment (Does the urban environment cause psychosis? and The schizophrenia envirome), poverty, migration, poor housing, racial discrimination, family dysfunction, double bind messages (Double bind – Wikipedia), bad sleep habits (Are bad sleeping habits driving us mad? by Emma Young), prenatal exposure to lead (which might double the risk) (Prenatal lead exposure linked to schizophrenia by Joanna Marchant), and unemployment. (Schizophrenia – Wikipedia, citations 60-65)

Looking more closely at what proximate mechanisms might be involved with the disease, studies indicate that inflammation as part of an overactive immune response is likely involved.  (Anti-Inflammatory Medications May Become A Treatment For Schizophrenia and Immune System Linked To Schizophrenia)  And glial cells, which play a key role in brain development, supporting the neurons, and fighting infection, have been suggested as a cause of the disease. (New schizophrenia theory by Alison Motluk)  (Of course, any mention of an overactive immune response leads me to bring up the topic of helminths as one potential therapeutic and preventive option.) (Autoimmune Therapies)

In looking for ways to develop a test for this disease researchers have noted that people who go on to develop schizophrenia lose their ability to identify smells before any clinical symptoms occur. (Could You Suffer From Psychosis? The Nose Knows) A blood test for schizophrenia might soon be available that is based on RNA molecules expressed from genes linked to the disease.  (Blood test for schizophrenia draws nearer by Marina Murphy)  Using brain imaging, researchers have shown that schizophrenic’s brains are much less reactive to images of bizarre facial images than controls. (Decoding Funny Faces To Detect Mental Illness) And another team of researchers has shown that children at high risk for later developing schizophrenia perform very poorly on tasks related to memory and executive functioning (planning, classifying, and interpreting information).  (Toward A Test For Childhood Detection Of Risk Of Bipolar Disorder And Schizophrenia

As for current treatments, factors which influence the likelihood of recovery include: “1) family relationships, 2) substance abuse, 3) duration of untreated psychosis, 4) initial response to medication, 5) adherence to treatment, 6) supportive therapeutic relationships, 7) cognitive abilities, (8) social skills, 9) personal history, and 10) access to care.”  (UCLA Study Names 10 Keys To Recovery From Schizophrenia

I do not have a citation for the source, but I remember once reading that in the United States years ago patients were treated by going to religious revival meetings.  They were in a supportive environment that made sense of their condition as a result of sin in the world.  This form of treatment was reported to have had a great deal of success until it broke down by being overwhelmed by the increasing number of patients.  Apparently a Hindu Temple can accomplish the same thing.  Researchers report that patients who spent six weeks in a temple had as much improvement as a month long course of standard drugs.  The secret is apparently a community that gives people a supportive environment, in tune with their own cultural beliefs, along with the hope of recovery.  (Temple treatment for psychiatric illness by Anil Ananthaswamy, Bangalore)

Looking at the more invasive types of treatments, researchers have found that electroshock can be productively combined with conventional drug therapies, making them more effective. (Electroshock Therapy Speeds Improvement In Schizophrenia Patients)   

An interesting fact about schizophrenics is that they see through the “hollow mask illusion.”  In controls communication between the parietal cortex, which is involved in the top-down control processing of visual information, and the lateral occipital cortex, which is involved in bottom-up processing, increased when the hollow faces were presented.  This did not happen with schizophrenics, which indicated that these different areas of the brain were unable to communicate normally. (Hollow Mask Illusion Fails To Fool Schizophrenia Patients

For those who might want to know what it’s like to be a schizophrenic, one doctor has recreated the experience of schizophrenia in a virtual second-life type of world.  (A Lever to Move the Mind)

Finally, to end on a somewhat positive note, some genes that increase the odds of schizophrenia also appear to increase creativity.  (Artistic tendencies linked to ’schizophrenia gene’ by Ewen Callaway)

Sun Protection Roundup

Saturday, September 26th, 2009

I’ve previously blogged about Iguana sunscreen, (Iguana SPF 45 Sunscreen).  This blog will be concerned with additional information regarding sun protection, but, before I cover this, I feel the need to point out that many people are chronically vitamin D deprived in modern society, and should be taking supplements if they aren’t getting much sun.  (See: Vitamin D Deficiency in Modern Society, and The Vitamin D Theory of Autism)

Some people don’t like to wear Iguana 45 every day, usually because they don’t like any sunscreen feel at all on their skin.  (Iguana isn’t bad in this regard, but it isn’t perfect either.)  If this is the case, Coppertone (Schering-Plough) makes shade, SPF 30, “Oil Free Gel,” in a 4 oz. bottle, with 2% parsol 1789 in it (a good UVA blocker).  While it isn’t as good as Iguana at UVB or UVA protection, waterproofing, or price; it is a decent sunscreen compared to most, and it’s very non-oily.  A person might wear it on a daily basis, and wear the Iguana 45 when they will be out a long time.  You can get it by ordering it through a pharmacy, if you can’t find it on the shelf.

For those relatively wealthy people among us, who don’t need or care about Iguana’s super waterproofing, and want as high protection as possible, they might take a look at these sunscreens: SVR 50+ Ultra Max, Photoderm MAX cream (SPF 100, PPD 31), and Anthelios XL (SPF 60, PPD 28, IPD 80).   

For an added layer of protection, Skinceuticals makes a range of antioxidant topical products (strongly recommended by a plastic surgeon I know) that help protect skin against photo-aging.  They do this by neutralizing free radicals and helping build collagen.

You can get sun protective clothing from such companies as: CoolibarSun Precautions, SunGrubbies, and Solar Eclipse.  

Rit Dye makes a laundry treatment product, “Sun Guard“.  You put it in the wash, and your clothes will have an ultraviolet protective factor of 30 for up to 20 washings.

People don’t realize the amount of skin damage they are incurring during the winter.  While UVB rays (the ones that will give you a sunburn) are less intense during the winter, UVA rays don’t vary as much by season or time of day.  UVA penetrates deeper, and plays a large role in skin aging and cancer.  So, while you might not burn, your skin is still being damaged.  Snow reflects UV, and fresh snow can almost double your dose.  UVA also penetrates most windows.  Regardless of the season the average person, who doesn’t sunbathe, gets about 19 hours of sun a week from just ordinary activities.  This adds up to about 1,000 hours a year in accumulated damage.  And by not wearing a sunscreen over the winter, you are damaging your skin as much as if you spent about 2 months of weekends at the beach in the summer. (Sunscreen in winter? No question about it by Linda Mooney from Prevention (Emmaus, Pa.). v. 51 no2, Feb. 1999, p. 70.)

“Melanotan and melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone that tend to induce skin tanning.  Unlike melanotan though, melanotan II
has the additional effect of increasing libido.  Both drugs were developed at the University of Arizona.  Researchers there knew that one of the best defenses against skin cancer was a natural tan which has been slowly developed over weeks.  They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body’s natural tanning system to produce a protective tan prior to UV exposure. They knew the body’s naturally occurring hormone alpha-melanocyte stimulating hormone caused melanogenesis, a process by which the skin’s tanning cells (melanocytes) produce the skin’s tanning pigment (melanin).  With that knowledge they tested to see if administering this hormone to the body directly could be an effective method to
cause sunless tanning. What they found was that while it appeared to work, natural alpha-MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to try and find a more potent and stable alternative, one that would be more practical”…. (Melanotan II – Wikipedia, Melanotan.org

Hippopotamus sweat may be the next big sunscreen ingredient, researchers say…Hippopotamus sweat has been found to protect against sun rays, bugs and skin infections, according to a
group of scientists at the University of California at Merced, who, The Nashua Telegraph reports, are now trying to chemically reproduce the animal’s sweat”…

If you are very sensitive to UV then fluorescent bulbs could be a bit of a problem, if you spend a significant numbers of hours a year under them (say 2,000 hours) without special plastic slip covers. These bulbs do put out some UV light (which is why you can grow plants under them), and while normal plastic covers help, some UVA does pass through them.  From the Xeroderma Pigmentosum Society, UV Notes, “Put in perspective, the exposure over one eight hour workday is equivalent to just over a minute of midday solar exposure on a clear July day in Washington, DC.”  This works out to about 4 hours a year of equivalent noon-time sun exposure from the fluorescent lighting in a typical office.

The art museum profession, which has to protect its paintings from the ravages of light, is well informed on this topic.  There are a number of companies which make these plastic slip covers, which aren’t very expensive.  One is the Solar Screen Co.; 53-11 105th Street, Corona. N.Y., 11368; (800)-347-6527, or (718)-592-8222.  An article on their products is: A Comparison of Selected UV Filtering Materials for the Reduction of Fading – by Patricia Cox Crews, in Journal of the American Institute for Conservation, Fall 1989, Vol. 28:2.  Another source of these special sleeves is Light Impressions, a company which sells supplies for the archival storage of photos, etc.  They can be reached at 1-800-828- 6216, and their address is PO Box 2100 Santa Fe Springs, CA. 90670.

From the research I have done, Cathode Ray Tubes found in computers and TV’s are safe.  So are regular tungsten light bulbs.  Xenon, Mercury, Quartz-iodine, Quartz-halogen, and Metal Halide are quite bad with regard to UVA.  Tungsten Iodine bulbs are about twice the regular ones (which doesn’t amount to much).  Sodium High and Low pressure bulbs are fine.
(See: “The Biological Effects of UVA Radiation” ed Frederick Urbach and Richard W. Gange, copy 1986; UVA-Emitting Light Sources by Maxim F. Mutzhas, pp. 10-23., and: “IES Lighting Handbook”, 1981, ISBN 0-87995-008-0, Fig. 8-21., and: “Museum Lighting” – Technical Bulletin 2, K.L. Maclead. Canadian Conservation Institute, National Museum of Canada, Ottawa, KIAOM8, April 1975.)

Philips’ SuperFlux LEDs are light emitting diode products that produce little or no UV, and can be used for indoor lighting.  Another company which makes such LEDs is the Wuppertal Institute.  

“An accidental discovery announced this week has taken LED lighting to a new level, suggesting it could soon offer a cheaper, longer-lasting alternative to the traditional light bulb…LEDs produce twice as much light as a regular 60 watt bulb and burn for over 50,000 hours.  The Department of Energy estimates LED lighting could reduce U.S. energy consumption for lighting by 29 percent by 2025. LEDs don’t emit heat, so they’re also more energy efficient.  And they’re much harder to break…” (Accidental Invention Points to End of Light Bulbs)

“Light from log fires produces no significant UV radiation.”
(From a letter by: Kenneth H. Kraemer, M.D., Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bld 37, Room 3E24, Bethesda, MD. 20892, 301-496-9033, e-mail: kraemerk@nih.gov)  Letter found at: http://www.xps.org/uvnotes.htm  

Here are a few companies which deal with UV protective film coatings for windows in both cars and homes: Gila Films, Llumar, Llumar UV-Shield, Vista Window Film, and Glassguard.

“We get about a million times more ultraviolet light directly from the sun than from moonlight“…. (When I asked an astronomer about how much UV we get from starlight, he sat down and calculated that it was vastly less than we get from the moon.) 

For more sun protection related information you might want to take a look at the Xeroderma Pigmentosum Society website.

Diabetes

Saturday, September 12th, 2009

Summing this blog entry up, I would say that the likely major ways of greatly reducing your risk of diabetes boils down to: getting enough vitamin D, having helminths (hookworms and whipworms), eating a Paleolithic Diet, engaging in intermittent fasting, exercising, getting enough sleep in complete darkness, consuming curry, cinnamon, and cloves; and avoiding toxins.    

I previously blogged about the theory that in Type I diabetes the beta cells aren’t dead, but instead malfunctioning pain cells in the pancreas are preventing them from producing insulin.  (A Cure for Diabetes?)  Of course, there are a quite a few more ideas out there about the condition:

In Finland, a cohort of infants born in 1966 were given vitamin D supplements of up to 8,000 IU/day, and had about 1/3 the rate of type I diabetes as other cohort groups.  (Intake of vitamin D and risk of type I diabetes: a birth-cohort study)   Finland later adopted a level of vitamin D supplementation closer to that of the United States, and their population naturally has lower levels of sun exposure, so today the blood levels of vitamin D there are likely very low.  Today Finland is the diabetes capital of the world.  (Finnish epidemic offers clues to diabetes)  (See also: Vitamin D Council

Helminths might play a role in preventing diabetes through down regulating the immune system.  (Review series on helminths, immune regulation and the hygiene hypothesis) (See also: Hookworms are our Little Friends)

The nitrates in our foods might be risk factors for Alzheimer’s, Parkinson’s, and diabetes.  These nitrates are found especially in bacon, cured meats, and ground beef; but they are also in such products as beer, cheese, water, rubber and latex products, cosmetics, fertilizers, and pesticides.  (Processed foods linked to Alzheimer’s and diabetes)  Avoiding such foods supports the argument for the Paleolithic Diet, which according to one man’s experience cured his type II diabetes. (Paleo Diet – So Easy a Caveman Can Do It!)  The Paleolithic Diet people argue that the high glycemic foods we eat cause chronic hyperinsulinemia, which leads to a host of diseases, including diabetes. (Hyperinsulinemic diseases of civilization: more than just Syndrome X)  Advocates of the sweetener Xylitol argue that it is ideal for diabetic patients.  (The Sweet Miracle of Xylitol, and Xylitol)  Celiac disease, which is an autoimmune disease caused by an immune reaction to the gluten found in grains,  is associated with a number of conditions, including diabetes, short stature, infertility, and anemia.  (Largest Study Ever Finds That One Out of Every 133 Americans May Have Celiac Disease

Intermittent fasting can help prevent diabetes and brain deterioration.  (Meal Skipping Helps Resist Diabetes, Brain Damage, and Posts Tagged ‘Intermittent Fasting’)

Exercise reduces the risk of diabetes through weight control, growth factor changes, and the reduction of inflammation. (Exercise builds brain health: key roles of growth factor cascades and inflammation, and Changes in Vigorous Physical Activity and Incident Diabetes in Male Runners)  In one study, multiple short duration exercise sessions of 3 x 10 min/day are superior to 1 x 30 min/day in glycemic control.  Cardiovascular fitness improvements were similar for the two groups.  (Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus)  Apparently 4 x 30 second sprints 3 times a week can greatly reduce the risk of diabetes and heart disease.  (Short fast sprints ‘cut’ diabetes, and Extremely short duration high intensity interval training substantially improves insulin action in young healthy males)

Heavy snoring, sleep apnea, and insomnia have been implicated in cardiovascular diseases, cancers, and diabetes.  Researchers have found that losing even a single night’s sleep causes the immune system to turn against healthy tissues in an autoimmune reaction.  (Getting a Handle on Why We Sleep)  The book, Lights Out: Sleep, Sugar, and Survival argues that our lack and sleep, and especially darkness, fouls up our hormonal systems; this greatly contributes to such diseases as diabetes, depression, heart disease, and cancer.  The author advises getting enough sleep, and sleeping in total darkness. (See also: Posts Tagged ‘Sleep’

Nursing an infant reduces his/her later risk of diabetes, cancer, allergies, infections, and arthritis. (Nursing Mothers…But Still Best for Babies)

Men with short legs, possibly caused by malnutrition during their first three months of gestation in utero, are at increased risk for diabetes and cardiovascular disease.  (Men with Short Legs More Likely to Suffer Heart Attacks

Large amounts of curry (turmeric) stops diabetes in diabetic mice.  (Curry for Diabetes)  Cinnamon and cloves improve risk factors for diabetes and heart disease.  (Cinnamon, Cloves Improve Insulin Function)  Dr. Richard A. Anderson found that doses of 1 to 6 grams of cinnamon daily improved blood profiles of diabetic patients.  (A Spoonful of Cinnamon Helps Treat Diabetes)

Exposure to pesticides and air pollution have both been linked to diabetes.  A major chemical accident happened in Seveso Italy, and years later those townspeople with higher levels of persistent organic pollutants in the fat in their bodies suffered much higher levels of type II diabetes.  (Could the diabetes epidemic be down to pollution?)  The use of the pesticide trichlorfon has been found to increase the risk of diabetes by 85%.  (Pesticides linked to diabetes risk)  Arsenic might be a risk factor for diabetes, since people with traces of it in their urine are more likely to suffer from it.  (Are Traces of Arsenic in Tap Water Linked to Diabetes?)

Gastric bypass can cause remission in Type II diabetes independently of weight loss or obesity.  What might be happening in that the upper intestines, the duodenum and jejunum, produce a regulatory hormone, anti-incretin, which is activated by the passage of food through this part of the intestine.  Anti-incretins lower the insulin level, and incretins raise it; and together they regulate its levels.  Researchers speculate that diabetics produce excess anti-incretin, which drives down their insulin, and block its action.  (Rethink On Cause of Type 2 Diabetes

The malarial drug hydroxychloroquine HCQ might prevent the development of diabetes in arthritic patients.  (Antimalarial Drug Prevents Diabetes in Arthritis Patients, Study Suggests)

The risk of getting Alzheimer’s doubles if a person has diabetes before age 65.  (Getting Diabetes Before 65 More Than Doubles Risk for Alzheimer’s Disease)  And Alzheimer’s might be a third form of diabetes.  (Discovery supports theory of Alzheimer’s disease as a form of diabetes)  (See also Alzheimer’s)  Children of mothers with autoimmune diseases, such as diabetes, arthritis, and celiac disease, have up to three times the risk of getting autism.  (From Gut Buddies, Autism May be Linked to Mom’s Autoimmune Disease)

It’s little surprise that misinformation regarding diabetes comes from our government, and it’s likely that the diabetic dietary guidelines recommend such a high level of grain consumption they actually increase your chances of becoming diabetic.  (The Best Way to Get Diabetes: Follow the Diabetes Dietary Guidelines)  Also, the GI index is very over simplified.  (GI Blues: What’s wrong with the GI Diet? Interindividual Variability and Intra-Individual Reproducibility of Glycemic Index Values for Commercial White BreadGlycemic Index Values Vary from One Test to the Next)  More misleading information comes from the book, The China Study, which concludes that there is a strong relationship between consuming animal products and numerous diseases, such as diabetes, cancers, heart disease, autoimmune diseases, etc.  Of course, the Paleolithic Diet people would argue that this is because of the types of meats we consume, which come from domesticated grain fed animals.  This relationship wouldn’t exist if the animal products people ate were from healthy grass consuming wild animals.

Pregnancy & Child Related Information

Wednesday, September 2nd, 2009

I’ve previously blogged about how geophagy (eating clay) has been practiced for thousands of years to prevent morning sickness.  Pregnant women become hyper-sensitive to environmental toxins, and morning sickness helps protect the developing fetus from deformities.  It now turns out that all that misery could pay off for yet another reason, because women who have a greater degree of morning sickness might have more intelligent babies.  (Morning Sickness may be Sign of a Bright Baby)  The researchers involved theorize that the hormones which cause it might also protect a baby’s brain.  

S. Boyde Eaton, et al., have written (Dietary Intake of Long-Chain Polyunsaturated Fatty Acids during the Paleolithic, p. 20) that our brains are somewhat smaller than our Paleolithic ancestor’s brains, and that one reason might be our modern dietary deficiency in DHA omega-3 fats.  Along with DHA, it seems that, for rats, enriching the environment of the mother long before she becomes pregnant can affect the learning of her offspring.  Researchers theorize that the mother’s learning affects the nature of the hormones she will release during her later pregnancies.  This will affect epigenetic chemical markers on her offspring’s genes, which will in turn affect these genes’ expression during brain development, finally causing changes in the brains of the pups.  (Can Experiences be Passed on to Offspring? and A Mother’s Experience can Alter her Offspring’s Memory Performance)  Meanwhile, stress during pregnancy very likely harms a baby’s brain, and might increase the risk of schizophrenia.  Researchers think the mechanism is likely related to the stress hormone cortisol crossing the placenta.  (Stress Harms Baby’s Brain While in Womb)  Another possible factor that could increase the risk of schizophrenia is having the flue during pregnancy. (Flue During Pregnancy may Increase Risk of Schizophrenia in Certain Offspring

There are some indications that vitamin D deficiency is a risk factor for preeclampsia.  (Vitamin D for the Prevention of Preeclampsia?  A Hypothesis.)  This is a condition that occurs in pregnancy, which causes the patient to develop hypertension, along with protein in their urine.  It’s widespread, affecting about 10% of pregnancies, and is currently only treatable through termination.  It is most common in first pregnancies, and some researchers think that it’s the result of the mother’s immune system inappropriately attacking fetal cells.  The theory is that they are being triggered by the foreign antigens that were introduced by the father.  So, besides vitamin D supplementation, another recommendation is to delay pregnancy for a while after beginning sexual relations, on the theory that this allows the mother’s immune system to become acquainted with the father’s sperm’s antigens.  (Introduction and Overview of Evolutionary Medicine (p.24) by Wenda R. Trevathan, et al.) 

Low levels of vitamin D are also associated with chronic pain and muscle weakness, which suggests this might be a possible factor in a painful difficult birth. (Lack of Vitamin D Linked to Pain, and Recent Developments in Vitamin D Deficiency and Muscle Weakness Among Elderly People)  Stephan Guyenet, of Whole Health Source, reports that pelvic inlet depth index was larger in our hunter-gatherer ancestors (97.7% versus 92.1% today), and that this might be still another reason why childbirth is difficult for modern people.  (Longevity & Health in Ancient Paleolithic vs. Neolithic peoples)  Because vitamin K2 deficiency narrows the bone structure of the face, it seems natural to speculate that this could also be part of the reason for our lower pelvic inlet depth index today. 

Difficult births lead to caesareans, and, using MRIs, researchers have been able to show that women who have had c-sections had lower response levels to their baby’s cries.  This might indicate weaker bonding with their infants.  Researchers suggested that this possibly occurred because these women missed out on the hormonal priming from oxytosin that takes place during a vaginal delivery.  (C-sections may Weaken Bonding with Baby)  

Home birthing is as safe as in the hospital.  Two studies, one from the Netherlands and the other from Canada, found no evidence of greater death rates among home births, for low risk pregnancies, in either the mothers or their babies.  In the Netherlands study nearly 1/3 of those who started at home did end up being transferred to the hospital, but the risk was no greater than those mothers who had started out in the hospital.  Researchers said that a good midwife was the key. (Home Births “as Safe as Hospital,” and Home Birth with Midwife as Safe as Hospital Birth, Study) (See also: The Natural Family Site, and Why Have Natural Childbirth?) 

Also, as I previously blogged, some people claim that placenta eating can prevent postpartum depression.  (Placenta Benefits.info)

The natural childrearing people argue against circumcision on a number of grounds, including that they believe there doesn’t seem to be much of a reason for it.  (Put Down that Knife!  11 Reasons not to Circumcise, Circumcision – Wikipedia, and Circumcision Rates)

Pacifiers reduce the risk of sudden infant death syndrome (SIDS) by about 90%.  (Pacifier Greatly Reduces Risk of Sudden Infant Death)  They reduce the risk regardless whether or not the infant sleeps on his/her stomach, in soft bedding, or his/her mother smoked.  Problems such as thumb sucking, tooth development, and difficulties breast feeding can be avoided by waiting a few weeks before using one, and stopping when they become toddlers.  (However, there apparently is a trade-off, because, according to Gabe Mirkin, studies from Finland found that children who use pacifiers are more likely to have recurrent ear infections.)  Other people also recommend co-sleeping as protective.  (See below)  One more way of lowering the risk of SIDS is by using a fan to circulate the air in the room.  This reduces the risk by 72%. (Fan Use Linked to Lower Rate of Sudden Infant Death)  (See also: Sudden infant death syndrome – Wikipedia)

Coming to very similar conclusions as The Continuum Concept by Jean Liedloff, here is an article on Evolutionary Psychology: Natural Parenting - Back to Basics in Infant Care by Regine A. Schon.     Matt Metzgar wrote up this outline.  (I inserted some additional materials and links):  

Evolutionary Function of Crying (For a second opinion see: Should Infants be Allowed to Cry Themselves to Sleep?)

  • Crying signals genuine needs of the infant
  • Crying should be immediately attended to by the mother or caregiver
  • Crying takes significant physical effort on the part of the infant
  • The immediate response to crying should be to restore physical contact between the caregiver and the infant

Infants as Carried Young

  • Hunter-gatherer women carried their infants in slings close to the body
  • This increased beneficial skin-to-skin contact between the mother and the infant
  • The common leg positions of babies suggest they are adapted for carrying

Cosleeping  (Regarding co-sleeping: Mr. Metzgar cites this article (which argues in favor of it), Why Babies Should Never Sleep Alone: A Review of the Co-sleeping Controversy in Relation to SIDS, Bedsharing, and Breastfeeding, and this site, Mother-Baby Behavioral Sleep Laboratory.  See also: The Benefits of Co-Sleeping)       

  • Cosleeping for the infant and mother has been the universal norm throughout most of human history
  • Bedsharing is the environment to which the vulnerable newborn is best adapted
  • Cosleeping may reduce some forms of SIDS

Breastfeeding (See also: Breastfeeding Linked to Smarter Babies (Again)  This article points out that, as well as being correlated with 5.9 points of higher IQ, breastfeeding also apparently reduces the chances of a mother later developing rheumatoid arthritis, and lessons the child’s odds of later developing cardiovascular disease.  This article, Big Bad Cavities: Breastfeeding is not the Cause, states that more than three dozen studies have shown no link between breastfeeding and the disease of Early Childhood Carries (ECC).  Medical News Today reports that the concentration of volatile organic compound toxins in breast milk are much lower than indoor air, and also much lower than the safe levels for drinking water. (Concentrations of Certain Toxins in Breast Milk are Low, Study Finds))

  • No alternative to breast milk existed before the transition to a farming economy
  • Therefore, infants have been breastfed for 99% of all human existence
  • Artificial substitutes have been unable to replicate the complex structure of breast milk
  • There is mounting evidence about the many benefits of breastfeeding on child development

Extrogestation

  • Human infants are born in an exceptionally immature state
  • The conditions for the early part of infant life should attempt to mimic that of the womb
  • This includes close contact with the mother’s body in a tight, warm embrace
  • Heartbeat sounds are comforting to an infant; women tend to hold infants on the left side of their body, close to their hearts
  • Rocking an infant provides a calming effect since it mimics the movement stimulation the infant received from the mother’s normal daily movements
  • Swaddling replicates the feeling of the womb and has been proven effective in calming infants

Toilet Training  (What is Infant Potty Training, Benefits of Infant Potty Training, Infant Potty Training, The Controversy over Infant Potty Training, Shaping self-initiated toileting in infants)  (There are also major health benefits of squatting instead of sitting for defecation.  (The Squat Toilet)  The repeated refrain is to do things the way nature intended.)

  • Infants were historically toilet trained much earlier than in modern times
  • Natural toilet training depends on reading an infant’s signals and responding appropriately
  • Children trained in this way complete toilet training anywhere from 6 months to 2 years

Matt also reviewed this book, The 90-Minute Sleep Baby Program.  As he says, the basic idea behind the book is that humans have a 90 minute cycle of activity and rest.  This means that when a baby wakes up their next nap should be 90 minutes later.  (Older children might string several of these together.)  22 out of 27 reviews on Amazon gave the book 5 stars.  Matt speculates that many children today are sleep deprived, which is obviously troublesome.  It turns out that sleep deprived children have twice the risk of becoming obese.  (Sleep Deprivation Doubles the Risk of Obesity in Both Children and Adults

Matt also very favorably reviewed, The Happiest Baby on the Block.  The author argues that babies need a uterus like environment, and he suggests a number of tactics for mimicking it.  These include swaddling, shh sounds, side/stomach position, swinging, and sucking.  He claims that his program will calm almost all babies.  

Matt also pointed out Baby Sign Language, which allows the infant to communicate his/her needs at a much younger age.  I think it’s very surprising that this wasn’t stumbled upon thousands of years ago, yet it is a remarkably simple and wonderful advancement.  It apparently isn’t some sort of silly fad, but brings real benefits, which I think all parents would appreciate, including greatly reduced frustration on everyone’s part, and increased language skills. 

Matt has blogged about Baby Led Weaning, which takes the position that children shouldn’t be fed pureed foods (Pureed Food “isn’t Natural for Babies’), but instead weaned directly onto solid foods.  The argument behind the idea is that this is much closer to the way our ancestors would have done it.  (It should be said that hunter-gatherers often did pre-chew the child’s food to help him/her along.)   

I have blogged before about going barefoot, and children who go barefoot as long as possible have about half the rate of flat footedness later on.  Having said that, being flat footed doesn’t appear to be as big a problem as people once thought.  There appears to be no relationship between the height of children’s arches and their ability to perform athletically, and it very well also might not affect their injury rates. (Flat Feet don’t Impair Kid’s Motor Skills)  

A study from Sweden concluded that risk factors for snoring as an adult include respiratory and ear infections as a child, being raised in a large family, and being exposed to a dog at home as a newborn. (Have A Dog? Your Child is More Likely to Snore as an Adult) 

Children who suffer from cyclic vomiting might actually be suffering from migraines. (Gabe Mirkin: Cyclic Vomiting

Low levels of carbon monoxide, 25 parts per million, might cause oxidative stress on the cochlear nerve, and permanently damage the hearing of children.  Such carbon monoxide can come from tobacco, cooking, and heating appliances.  (How Chronic Exposure to Tiny Levels of Carbon Monoxide Damages Hearing in Young Ears)  However, the main cause of hearing loss in modern world is loud noise.  The blast from a single gunshot, or the loud prolonged noise of a rock concert, can result in permanent hearing loss and tinnitus (ringing in the ears).

Many cases of bed-wetting might be caused by breathing problems.  63% of bed-wetting children stopped when they had surgery to remove their adenoids or tonsils, and the use of a plate to widen the palate of bed-wetters with narrow palates ended the condition in 70% of cases. (Breathing Troubles the Cause of Bed-wetting?)   Gabe Mirkin discusses another theory, that it’s the lack of antidiuretic hormone that causes the problem.  This hormone causes the kidneys to shut down at night.  (Bedwetting

The BBC reports that a 10 minute test for dyslexia has been developed that can be used starting at age 3 & 1/2.  (Early Warning Test for Dyslexia)  The test has children repeat sentences and re-tell a story while looking at how the child builds sounds up into words.  For parents of children who seem a little different there is the book, Quirky Kids: Understanding and Your Child Who Doesn’t Fit In- When To Worry And When Not To Worry.  One reviewer thought the book would be most helpful to parents who are just beginning to suspect something is unusual, but don’t know what might be the problem.  It also debunks a number of folk myths out there, and reportedly has a good section on the pros and cons of various medications.  Science Daily has this article, Specific Behaviors Seen in Infants Can Predict Autism, New Research Shows, which reports that Canadian researchers have discovered that there are behavioral signs that can accurately predict autism in children as young as one year old.  (See also: The Vitamin D Theory of Autism)

According to a study by the University of Rochester Medical Center, there is no detectable risk to children from the mercury in the seafood their mother’s ate, up to 12 servings a week.  The study period was before birth to age 9, and the children were tested for 21 different cognitive, neurological and behavioral functions.  These abilities included concentration, attention, problem-solving, and motor skills. (No Detectable Risk From Mercury in Seafood, Study Shows

Tonsils serve to trap germs and train the white blood cells when children are young, but as they grow older their importance lessons.  Doctors generally seem to say that their removal can be justified if they obstruct the throat, or the child suffers from frequent throat infections.  (Dr. Alan Green on Tonsil Removal)    

Not surprisingly, mother’s who talk about people’s mental states, such as beliefs, wants, and intentions, have children with a greater understanding of social interactions.  (This obviously does not establish causation, because mothers with greater social skills might pass on genes that also dispose their children to have those same skills.)  Researchers note that these greater social skills do not necessarily imply that these children will be better behaved. (The Secret to Building Children’s Social Skills)   The Incredible Years is an organization which hosts a variety of programs for teaching parents, teachers, and children social skills.  It turns out the ability of a mother to read her child’s emotions is more important than her social status for the child’s development. (Why Mind-Reading Mums are Best

Not surprisingly, children are happier who have a sense of spirituality, that is meaning in life, and they think that their lives have value.  Good interpersonal relationships also helped, and accounted for 27% of the happiness variation between children.  Being more sociable was also a happiness predictor.  (Spirituality is key to kids’ happiness

Researchers want to know why some children are resilient in spite of bad upbringings.  They have found that resilient children tend to share a number of characteristics:  They have at least one supportive person in their life, have a positive outlook, a pleasant altruistic personality, they are eager to learn, and have problem-solving skills.  They take responsibility for their mistakes, and move on.  They also have an interest or friend they can turn to when they need to.  (This description to me sounds somewhat like the characteristics of lucky people.)  (Raising Resilient Children Foundation, their book, Psychosocial Characteristics of Resilient Children, and The Resilient Child)

Sara Bennett and Nancy Kalish, in The Case Against Homework: How Homework is Hurting our Children and What We Can Do About It, argue that there’s almost no evidence that homework helps kid’s academic success.  They point out that the amount of homework has skyrocketed in recent years, which is contributing to an epidemic of obesity, and robs kids of the time they need to be kids.  They also give advice on how to separate useful assignments from the time wasters.  Richard Louv, author of, Last Child in the Woods, argues that children suffer from a nature-deficit disorder. 

For preventing myopia, besides a low glycemic diet/ Paleolithic Diet, it seems that playing outside is also protective.  Researchers in Australia have found that kids who spend a lot of time outside have lower myopia rates. (Kid’s eyes need the great outdoors)   

I have previously blogged about The Freedom to Learn site.  Peter Gray has a series of articles which argue that play is essential for healthy human life, and maintaining a band’s existence.  John Holt takes a similar approach in his books, How Children Learn and How Children Fail, that children are natural learners, and the process of forcing them to learn in school changes their personalities for the worse.  David Elkind’s book, The Power of Play: How Spontaneous Imaginative Activities Lead to Happier Healthier Children, argues that play is changing from teaching children social roles, vocations, and academic skills to teaching them brand loyalty, fashion consciousness, and group think.  Matt Metzgar reviewed Susan Linn’s book, The Case for Make-Believe: Saving Play in a Commercialized World, which argues that many of today’s toys are scripted, and that they don’t foster the development of social and critical skills.  Matt also discussed this article, Sucker-Me Elmo, which questions the merits of electronic toys.  Meanwhile, New York City is developing the next generation playground, which is designed to foster the imagination of kids. (New York developing a next-generation playground)  Here is a site that features educational products for children We Make Stories, which allows the child to write and print their own stories.

It turns out that pedophiles don’t randomly search through MySpace sites searching for kids.  Instead they go for those kids in chat rooms who are presenting themselves in sexually suggestive ways. (Welcome to Crimes Against Children Research Center, and Salon – Stop Worrying about your Children)  This information is from the same woman who runs Free Range Kids, which I have written about before.  Boing Boing favorably reviewed this book, If Your Kid Eats this Book Everything will Still be Okay: How to Know if Your Child’s Injury or Illness is Really an Emergency by Lara Zibners.  Zibners is an emergency room pediatrician who says that 75% of late night emergency room visits are unnecessary, and this book is a guide to all the things you don’t have to worry about.

On the other hand, there are real risks out there, and Dreambaby makes safety products to help reduce these.  Science Daily has a story, Homes Need More Protection Against Falls, which points out that falls are the second leading cause of death among children, and that this is because many homes have inadequate protection against them.  Such homes are lacking such commonsense things as banisters, grab bars, anti-slip bathtub strips, and child safety gates.  Eco Child’s Play has a similar outlook, and advocates ”Green Parenting for Non-Toxic Healthy Homes.”  This site focuses on alternative medicine, and sources of toxins from such things as plastics, medicines, and cleaners.  (See, for example: 12 Warnings for Parents and Kids in 2008, 10 Ways to Avoid Toxic Plastic - BPA (Bisphenol A), Synthetic Estrogens and Your Child, Smart Medicine for a Healthier Child, 9 Best Articles for Natural and Home Remedies on Echo Child’s Play in 2008, Another Reason We Can’t Trust the FDA, Melamine…, New Study Suggests Link Between Hairspray Exposure and Genital Birth Defect, How Safe is Your Child’s Playground?, Balloons Cause More Deaths than Marbles, and Finding Safer Products for our Children)  They also discuss products to make parent’s lives easier. (Postpartum Bamboo Belly Wrap Helps Shrink Your Belly and Prevent Stretch Marks, and Why Tilty is a Better Sippy

In recent years people have been taking bullying far more seriously, and researchers have found that, at least with rats, bullying might scar the brain for life.  When rats were bullied new brain nerve cells would form, but then die, and they acted depressed.  (Bullying May Scar Brain for Life

Psychologist Randall Flanery has this advice for being a great dad:  Run a benevolent dictatorship.  Be friendly, but not a friend.  Admit when you’re wrong.  Remain firmly flexible.  Stick around even when they don’t want you to.  Ask questions.  Don’t take it personally if they express unhappiness.  Know that parenting is 24/7, and then some.  Keep in mind that who you are is more important than what you buy them.  Laugh.  Of course, there is also the book, Supernanny: How to Get the Best from your Children by Jo Frost.  For the sport parent, there is Who’s Game is it Anyway: A Guide to Helping Your Child Get the Most From Sports, Organized by Age and Stage by Amy Baltzell.

Alzheimer’s

Saturday, August 15th, 2009

In a previous blog I discussed the Cycad Hypothesis of Alzheimer’s, which postulates that excitotoxicity caused by BMAA toxin from cyanobacteria might be the root cause of the disease.  However, there are many other possibilities.

If I had an identical twin who had developed Alzheimer’s, I would consider everything I could think of to prevent it.   The short list would probably include:  I would eat a Paleolithic Diet, intermittently fast, practice good dental hygiene, exercise, take vitamin D supplements, folic acid, omega-3 fats, curcumin, Longevinex, green tea, and resveratrol.  I also would avoid STDs, concussion-risky sports, toxins, radon, electromagnetic fields, heavy cell phone use, and heavy metals. 

Come to think of it, this just sounds a lot like extremely healthy living.  Below are the details:

The disease has an obvious genetic component, since having a family history of Alzheimer’s increases your risk, as does having an identical twin with it (concordance is 59%).

A relatively new theory is that it is a third form of diabetes.  (Alzheimer’s could be diabetes-like illness, study suggests)  It turns out that the brain produces its own insulin.  In Alzheimer’s the brain’s insulin production, as well as its ability to respond to insulin, drops off as the disease becomes more severe.  Brain cells also lose the ability to respond to insulin growth factors, and when rats were treated with related insulin-like growth factors to correct for this lack of response the typical loss of learning and memory was prevented.  Regular diabetes itself is also a risk factor for the disease.

A moderate or severe concussion will roughly double your later risk of Alzheimer’s.  (Study bolsters head injury, Alzheimer’s link)  This is also true of mild repetitive head injuries.  (Fortunately isolated mild concussions don’t seem to increase your risk.) 

Besides avoiding head trauma, having a generally healthy cardiovascular system and avoiding atherosclerosis helps avoid the disease.  Having moderately high cholesterol and a diet higher in saturated fats are risk factors.  Atrial fibrillation makes it 44% more likely you will get it.  Cardiovascular disease increases your risk by 30%.  And if you’ve had a stroke your chances go up by nearly 50%.  Being obese, metabolic syndrome, and smoking during midlife all put you at greater risk.

Researchers suspect that early nutrition, as indicated by various body measurements, might play a role.  Women with short arms have a 50% greater risk, while a longer shin length is protective. 

Various viruses and microbes can worsen your chances.  Viruses in the herpes family (simplex I, Cytomegalovirus V, and simplex VI) are strongly suspected of being causal factors.  One theory holds that the microbe Chlamydia pneumonia might be the main agent responsible.  Lyme disease and Helicobacter pylori bacteria also are both associated with Alzheimer’s.  

A vasectomy might put men at risk for one rare form of dementia, Primary Progressive Aphasia.  

Vitamin D keeps proving its worth, since low levels of vitamin D have been linked to cognitive decline.  (See also Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease)  

The inhaled anesthetics halothane and isoflurane are linked with amyloid beta buildup.  Childhood lead exposure could increase the risk.  Processed food that contains nitrates might be linked to Alzheimer’s, diabetes, and Parkinson’s.  Other possibilities include mercury, aluminum, and zinc exposure, non-wine alcohol consumption, and work related organic solvent exposure.

Although the lines of causation are far from clear, Alzheimer’s correlates with other mental problems.  Being lonely (an active social life is protective), having a history of depression, and having a major psychiatric illness all increase your chances of getting it. 

Additional correlating factors include:  having poor dental health, being exposed to air pollution,  a history of manual work, a family history of Parkinson’s, maternal age at birth, number of pregnancies, (possibly) exposure to low magnetic fields (Qiu et al, 2004) (Occupations with Exposure to Electromagnetic Fields: A Possible Risk Factor for Alzheimer’s Disease, Do Cell Phones Cause Alzheimer’s? By Maggie Spilner), and age.  There have also been concerns about radon’s radioactive daughter products being found in the brains of Alzheimer’s patients at ten times the normal rate. (Alzheimer’s & Parkinson’s – Could the Cause be Radon?)  

In addition to the above list, here are some more controllable factors that people have suggested:  

Exercise has been shown to slow memory loss.

Dietary restriction and intermittent fasting seem to protect against a large variety of diseases, including Alzheimer’s.  (See also Extreme Diet Nixes Alzheimer’s)  A low carbohydrate and high fat diet has been shown to improve Alzheimer’s disease in mice.  In one study drinking fruit and vegetable juices cut risk by 76%.  The Mediterranean diet also seems to be protective.  Although I haven’t seen any studies on it, given all the lines of evidence I’m pointing out in this blog entry, I feel very confident in predicting that The Paleolithic Diet would be protective.

Having proper levels of folic acid reduces your risk by 55%, probably at least in part because of its effect on homocysteine levels.  Curcumin, which is found in the spice turmeric, appears to block amyloid plaques.  Many results suggest that the omega-3 fatty acid DHA is beneficial.  Silica in drinking water might help prevent the disease.  (See also Nature’s Way Silica Gel)  Huge doses of vitamin B3 have been found to stop the progression of Alzheimer’s in mice.  Marijuana has anti-inflammatory effects, and it might limit the memory loss part of it.  There is some speculation that Vitamin K2 could be beneficial.  Vitamin C and E consumption, coffee drinking, resveratrol, huperzine A, and wine consumption all might be somewhat protective.  (Since I am a teetotaler I’d consider using a product like Longevinex, which they claim has red wine’s benefits in a pill, without the alcohol or calories.)

Although it seems a bit extreme to suggest this as a preventive measure, Alzheimer’s does have an inverse association with cancer.  If this is true with those few cancers which are fully curable, and it were possible to somehow induce such a cancer, this suggests an unorthodox treatment option.

Looking in the doctor’s medicine cabinet, non-steroidal anti-inflammatory drugs, statins, antihypertensives (calcium antagonists), and vaccines for diphtheria, tetanus, polio, and the flue all might be protective.

Academic ability is a protective factor which probably indicates that you aren’t as susceptible to the disease.  A Canadian study showed that bilingualism delayed the onset of Alzheimer’s by up to four years.  A lack of schooling and farm upbringing seems to boost your risk.  (Of course, the farm environment suggests the possibility of chemical exposure as an additional risk factor.) 

Researchers are making progress on possible ways to diagnose the disease at earlier stages:

It turns out that the disease manifests tell-tell signs years before it becomes apparent, and that lower levels of abstract reasoning and recall for verbal materials at a young age are good predictors for Alzheimer’s many years later.  One study, the “Nun Study,” has shown that certain aspects of language usage in young adults are 85%-90% accurate in predicting the disease 50 years later.  The rational for focusing on this population of women was that they lived very similar lives; so many possible confounding variables were eliminated.  Researchers found that linguistic features of the essays these women wrote when they were entering the convent, when analyzed properly, were strongly predictive.  They found that grammatical complexity tells how well a person’s memory is functioning, and “Idea density,” which is the number of discrete ideas per 10 written words, predicts educational level, vocabulary, and general knowledge.  It turns out that idea density at a young age is very predictive of Alzheimer’s in old age.   

Researchers have found that normally people do better on a memory test if the words to be remembered are semantically related.  But people who later develop Alzheimer’s don’t do any better at such tasks, suggesting that they no longer have access to deeper semantic meanings.  The same scientists have also found that implicit memory tests are good for diagnosing Alzheimer’s in its early stages.  In one test, participants were required to read words from a computer screen as quickly as possible.  For healthy people if a word is repeated they will be primed and perform better.  This effect doesn’t tend to happen with people who will later develop Alzheimer’s, indicating they aren’t learning implicitly (learning without the awareness of learning, or being primed) when they perform a task.   

Researchers have developed a technique that allows them to image beta amyloid plaques in living mice.  They did this by using a non-toxic compound that binds to the plaques, which is then visible when scanned by using MRI.  It might turn out not be necessary to go to such lengths, because researchers have discovered that beta amyloid proteins also build up in the eye lenses of patients.  It therefor seems likely that a simple eye test will someday be available for the disease.  Some researchers speculate that it might be possible to develop a saliva test which would be able to detect Alzheimer’s.

As for what medicine might eventually have to offer:

British scientists claim that an experimental drug called Rember, which attacks the tangles that form during the disease, can reduce Alzheimer’s progression by about 80%.   In a small study, the anti-inflammatory arthritis drug Etanercept demonstrated remarkable benefits in patients.  Researchers are now testing a patch which delivers a vaccine that causes the immune system to break down beta Amyloid proteins.  If used early in the disease, the epilepsy drug Valproic Acid (VPA) has been shown to reverse memory loss, by inhibiting the production of these proteins.  A drug tested in the UK and Singapore, Methylthioninium chloride (MTC), blocks the accumulation of tau tangles inside brain cells, and slows the progress of the disease by 81%.  Dimebon, a Russian antihistamine, which seems to improve the functioning of mitochondria, stabilized Alzheimer’s in an 18 month study.  In Australia they have developed a drug PBT2 that attacks plaques.  Exelon, a cholinesterase inhibitor, seems to delay development of the disorder.  Researchers have found that they can increase the expression in the brain of the protein transthyretin, which seems to halt the progression of the disease.

Getting further into what sounds like science fiction, there is an experimental helmet which bathes the brain with infra-red light, which it is claimed stimulates the growth of brain cells and could reverse Alzheimer’s symptoms.  Finally, researchers have been experimenting with trepanation, drilling a hole in your head, on the theory that this increases cranial compliance.  This is the elasticity of the brain’s vascular system, and the theory is that increasing this will in turn increase blood flow to the brain. 

Here is an on-line article by William R. Ware that discusses many of the suspected causes that might be involved, in addition to the ones I have listed, they include: emotional stress, oxidative stress, vitamin deficiency, vitamin b12 deficiency, hypotension, hypertension, alcohol abuse, pesticides, and herbicides, low antioxidant levels, and a tendency for thrombosis.  (See also memory and cholesterol, low levels of cholesterol)  He also reviews the relative risk reduction of a number of drugs currently used to treat Alzheimer’s.  What the more successful drugs seem to have in common is antiangiogenic activity, or the inhibition of new vascularization.  Natural compounds which might have antiangiogenic activity include Omega-6 fatty acids, green tea, licorice, quercetin, squalamine, and shark cartilage.

Here are two positively reviewed books:  The Alzheimer’s Answer: Reduce Your Risk and Keep Your Brain Healthy by Marwan Sabbagh, which, at 330 pages, covers a lot of material; and Beyond Alzheimer’s: How to Avoid the Modern Epidemic of Dementia (Hardcover) by Scott D. Mendelson (See also: Beyond alzheimer’s – summary)

Finally, The Myth of Alzheimer’s: What You Aren’t Being Told About Today’s Most Dreaded Diagnosis by Peter J. Whitehouse provides a contrarian view of the disease.

The Vitamin D Theory of Autism

Tuesday, August 11th, 2009

John Jacob Cannell MD, of the Vitamin D Council, has written up his theory that Autism is largely a result of Vitamin D deficiency.  (Vitamin D Theory of Autism) Here is some of the evidence he cites in arguing for such a connection:

Seizures are common in children with autism, and vitamin D supplementation reduces the rate of seizures in those who have them.

Vitamin D deficiency increases chronic inflammation.  Autistic children have high rates of inflammation.

Estrogen has multiple potentiating effects on vitamin D, while testosterone doesn’t.  This suggests a protective role for estrogen when suffering from low vitamin D levels.  Boys have 4:1 greater odds of being autistic.   

Children with Williams Syndrome are highly social, empathic, and friendly; the exact opposite of autistic children.  Many of them have very high levels of vitamin D exposure during a certain period during their development.    

The epidemic of autism started around 1989, which is at the same time doctors started a widespread campaign advising people to use sunscreen.  Before 1985 autism correlated with latitude and sun exposure, but after sunscreen use became widespread it didn’t.

Blacks have higher rates of autism.

Vitamin D Deficiency in Modern Society

Tuesday, July 14th, 2009

There is a lot of information out there which indicates most people in America today are seriously vitamin D deficient.  This deficiency has been implicated in: cancers of the bladder, breast, colon, esophagus, kidney, ovary, prostate, rectum, stomach, uterus, and skin, as well as non-Hodgkin lymphoma. Other conditions connected with this deficiency are: early-onset (type 1) diabetes, heart disease, osteoporosis, high blood pressure, rheumatoid arthritis, seasonal affective disorder (SAD), and multiple sclerosis.  In addition, vitamin D deficiency is often misdiagnosed as fibromyalgia.  GrassrootsHealth is a group of researchers and doctors who are trying to get the word out.